Adenoma malignum: Report of a case with cytologic and colposcopic findings and immunohistochemical staining with antimucin monoclonal antibody HIK-1083

Shinji Sato, Kiyoshi Ito, Ryo Konno, Satoshi Okamoto, Akira Yajima

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7 Citations (Scopus)

Abstract

BACKGROUND: Adenoma malignum of the uterine cervix was first described by Gusserow. We report here a case with cytologic, histologic and colposcopic findings and immunohistochemistry for HIK-1083. CASE: A 42-year-old female was noted to have a probable adenoma malignum due to the detection of atypical cells classified as V. On colposcopy, comma-shaped, atypical vessels spread over the entire cervical area. Histologic findings were characteristic of tumor invasion beyond the layer of cervical glandular ducts. Immunohistochemical detection of CEA was negative, but HIK-1083, which recognizes gastric glandular mucous cells, was positive. CONCLUSION: For a definitive diagnosis of adenoma malignum of the cervix, immunohistochemical examination for an appropriate marker, such as HIK-1083, should be added to the routine gynecologic examination, cytologic and histopathologic examination, and colposcopy.

Original languageEnglish
Pages (from-to)389-392
Number of pages4
JournalActa Cytologica
Volume44
Issue number3
DOIs
Publication statusPublished - 2000 Jan 1

Keywords

  • Adenoma malignum
  • Cervix neoplasms
  • Exfoliative cytology
  • HIK- 1083
  • Monoclonal antibodies

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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