Abstract
Sensitivity to an inhibitor of epidermal growth factor receptor (EGFR) kinase strongly correlates with EGFR somatic mutations in non-small cell lung cancer. These mutations are frequently found in patients with adenocarcinoma, never- or light-smokers, women, and East Asians. In this study, we show an aggregation of three non-small cell lung cancer cases with EGFR gene mutations in one family. The subjects were all female, never- or light-smokers with adenocarcinoma. Two of the patients responded to treatment with gefitinib. A genetic study of these cases would be useful in elucidating genetic susceptibility to lung cancer in persons with EGFR mutations.
Original language | English |
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Pages (from-to) | 311-313 |
Number of pages | 3 |
Journal | Journal of Thoracic Oncology |
Volume | 3 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2008 Mar |
Externally published | Yes |
Keywords
- EGFR tyrosine kinase inhibitor
- Epidermal growth factor receptor (EGFR) gene mutation
- Familial lung cancer
- Non-small cell lung cancer
ASJC Scopus subject areas
- Oncology
- Pulmonary and Respiratory Medicine