Adenocarcinoma with epidermal growth factor receptor gene mutations in three siblings

Tomohiro Sakakibara; Yasuo Saijo; Tatsuro Fukuhara; Kazunori Gomi; Akira Inoue; Osamu Ishimoto; Shunichi Sugawara; Toshihiro Nukiwa

doi:10.1097/JTO.0b013e3181653cce

Adenocarcinoma with epidermal growth factor receptor gene mutations in three siblings

Tomohiro Sakakibara, Yasuo Saijo, Tatsuro Fukuhara, Kazunori Gomi, Akira Inoue, Osamu Ishimoto, Shunichi Sugawara, Toshihiro Nukiwa

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Sensitivity to an inhibitor of epidermal growth factor receptor (EGFR) kinase strongly correlates with EGFR somatic mutations in non-small cell lung cancer. These mutations are frequently found in patients with adenocarcinoma, never- or light-smokers, women, and East Asians. In this study, we show an aggregation of three non-small cell lung cancer cases with EGFR gene mutations in one family. The subjects were all female, never- or light-smokers with adenocarcinoma. Two of the patients responded to treatment with gefitinib. A genetic study of these cases would be useful in elucidating genetic susceptibility to lung cancer in persons with EGFR mutations.

Original language	English
Pages (from-to)	311-313
Number of pages	3
Journal	Journal of Thoracic Oncology
Volume	3
Issue number	3
DOIs	https://doi.org/10.1097/JTO.0b013e3181653cce
Publication status	Published - 2008 Mar

Keywords

EGFR tyrosine kinase inhibitor
Epidermal growth factor receptor (EGFR) gene mutation
Familial lung cancer
Non-small cell lung cancer

ASJC Scopus subject areas

Oncology
Pulmonary and Respiratory Medicine

Access to Document

10.1097/JTO.0b013e3181653cce

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title = "Adenocarcinoma with epidermal growth factor receptor gene mutations in three siblings",

abstract = "Sensitivity to an inhibitor of epidermal growth factor receptor (EGFR) kinase strongly correlates with EGFR somatic mutations in non-small cell lung cancer. These mutations are frequently found in patients with adenocarcinoma, never- or light-smokers, women, and East Asians. In this study, we show an aggregation of three non-small cell lung cancer cases with EGFR gene mutations in one family. The subjects were all female, never- or light-smokers with adenocarcinoma. Two of the patients responded to treatment with gefitinib. A genetic study of these cases would be useful in elucidating genetic susceptibility to lung cancer in persons with EGFR mutations.",

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AU - Sakakibara, Tomohiro

AU - Saijo, Yasuo

AU - Fukuhara, Tatsuro

AU - Gomi, Kazunori

AU - Inoue, Akira

AU - Ishimoto, Osamu

AU - Sugawara, Shunichi

AU - Nukiwa, Toshihiro

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