Adenocarcinoma with epidermal growth factor receptor gene mutations in three siblings

Tomohiro Sakakibara, Yasuo Saijo, Tatsuro Fukuhara, Kazunori Gomi, Akira Inoue, Osamu Ishimoto, Shunichi Sugawara, Toshihiro Nukiwa

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Sensitivity to an inhibitor of epidermal growth factor receptor (EGFR) kinase strongly correlates with EGFR somatic mutations in non-small cell lung cancer. These mutations are frequently found in patients with adenocarcinoma, never- or light-smokers, women, and East Asians. In this study, we show an aggregation of three non-small cell lung cancer cases with EGFR gene mutations in one family. The subjects were all female, never- or light-smokers with adenocarcinoma. Two of the patients responded to treatment with gefitinib. A genetic study of these cases would be useful in elucidating genetic susceptibility to lung cancer in persons with EGFR mutations.

Original languageEnglish
Pages (from-to)311-313
Number of pages3
JournalJournal of Thoracic Oncology
Volume3
Issue number3
DOIs
Publication statusPublished - 2008 Mar

Keywords

  • EGFR tyrosine kinase inhibitor
  • Epidermal growth factor receptor (EGFR) gene mutation
  • Familial lung cancer
  • Non-small cell lung cancer

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

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