Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing

Gowri Nayak, Kevin X. Zhang, Shruti Vemaraju, Yoshinobu Odaka, Ethan D. Buhr, Amanda Holt-Jones, Stace Kernodle, April N. Smith, Brian A. Upton, Shane D'Souza, Jesse J. Zhan, Nicolás Diaz, Minh Thanh Nguyen, Rajib Mukherjee, Shannon A. Gordon, Gang Wu, Robert Schmidt, Xue Mei, Nathan T. Petts, Matthew BatieSujata Rao, John B. Hogenesch, Takahisa Nakamura, Alison Sweeney, Randy J. Seeley, Russell N. Van Gelder, Joan Sanchez-Gurmaches, Richard A. Lang

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

White adipocytes activate the lipolysis pathway to produce the free fatty acids that are used as heating fuel by brown adipose tissue. Nayak et al. show that Opsin 3 is required for blue-light-enhanced activation of the lipolysis pathway. This explains the low body temperature of Opn3 mutant mice.

Original languageEnglish
Pages (from-to)672-686.e8
JournalCell Reports
Volume30
Issue number3
DOIs
Publication statusPublished - 2020 Jan 21

Keywords

  • OPN3
  • adipocyte
  • encephalopsin
  • light
  • lipolysis
  • metabolism
  • mitochondria
  • opsin
  • thermogenesis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing'. Together they form a unique fingerprint.

Cite this