Adaptive evolution of conger eel galectins

Ogawa Tomohisa, Shirai Tsuyoshi, Yamane Takashi, Kamiya Hisao, Muramoto Koji

Research output: Contribution to journalShort surveypeer-review

1 Citation (Scopus)


Two galectins isolated from the skin mucus of conger eel (Conger myriaster), named congerins I and II, are dimers composed of two identical subunits of 136 and 135 amino acid residues, respectively. They belong to the proto-type galectins and showed 48% sequence identity and different thermal stabilities and different sugar binding. The molecular evolutionary analyses and X-ray crystallography analyses of congerins I and II reveal that they have evolved in an accelerating and adaptive manner to the emergence of a new structure including domain-swapping manner and a unique new ligand-binding site. In this review, we summarize and discuss the structure-properties/function relationships and the molecular evolution of fish galectins.

Original languageEnglish
Pages (from-to)177-187
Number of pages11
JournalTrends in Glycoscience and Glycotechnology
Issue number77
Publication statusPublished - 2002 May


  • Adaptive evolution
  • Conger eel
  • Domain swapping
  • Galectin
  • X-ray crystallography

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry


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