Adaptive evolution of conger eel galectins

Ogawa Tomohisa, Shirai Tsuyoshi, Yamane Takashi, Kamiya Hisao, Muramoto Koji

    Research output: Contribution to journalShort surveypeer-review

    Abstract

    Two galectins isolated from the skin mucus of conger eel (Conger myriaster), named congerins I and II, are dimers composed of two identical subunits of 136 and 135 amino acid residues, respectively. They belong to the proto-type galectins and showed 48% sequence identity and different thermal stabilities and different sugar binding. The molecular evolutionary analyses and X-ray crystallography analyses of congerins I and II reveal that they have evolved in an accelerating and adaptive manner to the emergence of a new structure including domain-swapping manner and a unique new ligand-binding site. In this review, we summarize and discuss the structure-properties/function relationships and the molecular evolution of fish galectins.

    Original languageEnglish
    Pages (from-to)177-187
    Number of pages11
    JournalTrends in Glycoscience and Glycotechnology
    Volume14
    Issue number77
    DOIs
    Publication statusPublished - 2002 May

    Keywords

    • Adaptive evolution
    • Conger eel
    • Domain swapping
    • Galectin
    • X-ray crystallography

    ASJC Scopus subject areas

    • Biochemistry
    • Organic Chemistry

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