Acylation of Alkenes with the Aid of AlCl3 and 2,6-Dibromopyridine

Shinya Tanaka, Tsukasa Kunisawa, Yuji Yoshii, Tetsutaro Hattori

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Friedel-Crafts-type acylation of alkenes with acyl chlorides has been successfully conducted with a wide substrate scope by the combined use of AlCl3 and 2,6-dibromopyridine. Trisubstituted alkenes afford allylketones or vinylketones depending on the presence or absence of hydrogen atom(s) at the β-position to the acylation site, while monosubstituted alkenes exclusively afford vinylketones.

Original languageEnglish
Pages (from-to)8509-8513
Number of pages5
JournalOrganic letters
Volume21
Issue number21
DOIs
Publication statusPublished - 2019 Nov 1

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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