Acute Reduction of Functional Mitral Regurgitation in Canine Model Using an Epicardial Device

Masatoshi Akiyama, Zoran B. Popović, Keiji Kamohara, Faruk Cingoz, Masao Daimon, Chiyo Ootaki, Yoshio Ootaki, Maureen Martin, Jenny Liu, Michael W. Kopcak, Raymond Dessoffy, Kiyotaka Fukamachi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Purpose: This study evaluated the short-term feasibility of a novel epicardial device that treats functional mitral regurgitation by simultaneously changing the mitral and the left ventricular geometry. Description: We implanted a prototype device that consists of 2 tissue anchors, a deflector, and a flexible tightening chord in 7 mongrel dogs with heart failure and functional mitral regurgitation induced by rapid ventricular pacing. Hemodynamic and echocardiographic data were obtained before and after device implantation. Evaluation: The device acutely reduced the mitral regurgitation grade from 3.2 ± 0.3 to 0.9 ± 0.5 (p < 0.001). Left ventricular end-diastolic volume (79.6 ± 23.6 to 61.2 ± 16.9 mL; p = 0.004) and end-systolic volume (63.1 ± 17.3 to 49.2 ± 12.3 mL; p = 0.006) decreased substantially. End-systolic elastance significantly increased from 1.9 ± 1.0 to 2.6 ± 1.4 mm Hg/mL (p = 0.02). Device implantation did not alter coronary perfusion. Conclusions: The epicardial device acutely reduced functional mitral regurgitation and improved left ventricular geometry. Further studies are required to demonstrate the long-term safety and efficacy of this concept.

Original languageEnglish
Pages (from-to)1771-1775
Number of pages5
JournalAnnals of Thoracic Surgery
Issue number5
Publication statusPublished - 2008 May
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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