Acute combined central and peripheral demyelination showing anti-aquaporin 4 antibody positivity

Mari Kitada, Hidekazu Suzuki, Juri Ichihashi, Rino Inada, Katsuichi Miyamoto, Toshiyuki Takahashi, Yoshiyuki Mitsui, Kazuo Fujihara, Susumu Kusunoki

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Neuromyelitis optica spectrum disorder (NMOSD) is characterized by optic neuritis or transverse myelitis with anti-aquaporin 4 (AQP4) antibodies (1). We herein present the case of a patient with NMOSD who also was affected with peripheral neuropathy. A 58-year-old woman developed gait disturbance and sensory impairment in the lower limbs. She exhibited longitudinally extensive transverse myelitis with anti-AQP4 antibodies. Nerve conduction studies showed demyelinating changes. Laboratory findings showed hepatitis-C virus (HCV) infection. Her peripheral neuropathy improved after immunotherapy. There have been no previous reports of NMO or NMOSD associated with neuropathy. The HCV infection or undetermined humoral factors other than the anti-AQP4 antibodies may have caused her peripheral neuropathy.

Original languageEnglish
Pages (from-to)2443-2447
Number of pages5
JournalInternal Medicine
Issue number17
Publication statusPublished - 2012


  • Anti-aquaporin 4 antibody
  • Neuromyelitis optica
  • Neuropathy

ASJC Scopus subject areas

  • Internal Medicine


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