Acute allograft rejection and lymphocyte function in canine lung transplantation

S. Fujimura, Takashi Kondo, Y. Sohara, A. Yamauchi, M. Kawakami, M. Horikawa, T. Nakada

Research output: Contribution to journalArticlepeer-review


Studies on the responsiveness of lymphocytes to PHA were made on peripheral blood samples, cell suspensions of paratracheal lymph node, spleen, bone marrow and lung transplants undergoing rejection that were removed from a total of 21 dogs with a lung allograft. Histologic and immunofluorescent studies were carried out on sections from the lung allograft, the results of which were compared with those obtained from the cell culture studies. Four animals with autotransplanted lung were used as control. There was a wide range distribution in PHA activation of peripheral lymphocytes preoperatively. There was a high response group and a low response group with regard to peripheral lymphocyte responsiveness; in the recipient belonging to the former group, the values of blastogenesis were consistently reduced in the early period and increased thereafter within 1 wk postoperatively. There was a striking correlation between the values of PHA response of preoperative peripheral lymphocytes and those of the extract from the lung graft of 5 days age. In lymphatic tissue, the values of PHA response were decreased during the rejection process. Immunofluorescent studies of the lung allograft undergoing rejection revealed IgG containing cells in lung parenchyma but their populations were small as compared with infiltrating mononuclear cells without IgG in their cytoplasma. The results obtained indicate that lymphocytes, either T or B cells, collect into the lung allotransplant and are involved in a rejection process. Peripheral lymphocytes may be supplied by one recipient's lymphatic tissues during that process. However, the detailed roles and interaction of those lymphocyte subdivisions in rejection phenomena remain to be defined.

Original languageEnglish
Pages (from-to)10-19
Number of pages10
JournalScience Reports of the Research Institutes Tohoku University - Series C Medicine
Issue number1-2
Publication statusPublished - 1978 Dec 1

ASJC Scopus subject areas

  • Medicine(all)


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