Activities of antimicrobial agents against 8,474 clinical isolates obtained from 37 medical institutions during 2000 in Japan

Keizo Yamaguchi, Akira Ohno, Fusako Kashitani, Morihiro Iwata, Makoto Kanda, Yoshiko Tsujio, Naoki Watanabe, Hideaki Kawaguchi, Norihiko Shimoyama, Mitsuomi Kaimori, Yosei Katayama, Kumiko Sugimoto, Hiromi Tashiro, Minoru Yasujima, Akira Suwabe, Ritsuko Obata, Masayuki Tsuzimura, Tatsuro Sugiyama, Shunkoh Toyoshima, Jun KatoMitsuo Kaku, Keiji Kanemitsu, Hiroyuki Kunishima, Jun Okada, Jun Igari, Toyoko Oguri, Kiyoaki Watanabe, Yoshio Kobayashi, Hiroshi Uchida, Harushige Kanno, Kouichi Itoh, Masahiko Okada, Sugako Kobayashi, Akira Itoh, Midori Sumitomo, Hisashi Baba, Kazue Minakuchi, Shiomi Ishigo, Toshinobu Horii, Kiyoharu Yamanaka, Hidetoshi Okabe, Kenichi Tatewaki, Kunihiko Moro, Satoshi Ichiyama, Toshiharu Matsushima, Yoshihito Niki, Masao Kuwabara, Takeshi Kageoka, Toshiharu Hongo, Tomohiko Taminato, Kiyoshi Negayama, Hideichi Makino, Mitsuharu Murase, Hitoshi Miyamoto, Masahide Takii, Junko Ono, Tohru Takata, Naotaka Hamazaki, Toshiharu Tsutsui, Kazufumi Hiramatsu, Tetsunori Saikawa, Zenzou Nagasawa, Yousuke Aoki, Yoichi Hirakata, Sigeru Kohno, Keiichi Nakagawa, Nobuhisa Yamane

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)

Abstract

A survey was conducted to determine the antimicrobial activity of fluoroquinolones and other antimicrobial agents against 8,474 clinical isolates obtained from 37 Japanese medical institutions in 2000. A total of 25 antimicrobial agents were used, comprising 4 fluoroquinolones, 13β-lactams, minocycline, chloramphenicol, clarithromycin, azithromycin, gentamicin, amikacin, sulfamethoxazole-trimethoprim, and vancomycin. A high resistance rate of over 85% against fluoroquinolones was exhibited by methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus faecium. Isolates showing resistance to fluoroquinolones among methicillin-resistant coagulase-negative Staphylococci, Enterococcus faecalis, and Pseudomonas aeruginosa from UTI accounted for 30-60%. However, many of the common pathogens were still susceptible to fluoroquinolones, such as Streptococcus pneumoniae (including penicillin-resistant isolates), Streptococcus pyogenes, methicillin-susceptible S. aureus (MSSA), methicillin-susceptible coagulase-negative Staphylococci, Moraxella catarrhalis, the Enterobacteriaceae family, and Haemophilus influenzae (including ampicillin-resistant isolates). About 85% of P. aeruginosa isolated from RTI were susceptible to fluoroquinolones. In conclusion, this survey of sensitivity to antimicrobial agents clearly indicated trend for increasing resistance to fluoroquinolones among MRSA, Enterococci, and P. aeruginosa isolated from UTI, although fluoroquinolones are still effective against other organisms and P. aeruginosa from RTI as has been demonstrated in previous studies.

Original languageEnglish
Pages (from-to)341-364
Number of pages24
JournalThe Japanese Journal of Antibiotics
Volume56
Issue number5
Publication statusPublished - 2003 Oct

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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