Activities of antimicrobial agents against 5,180 clinical isolates obtained from 26 medical institutions during 1998 in Japan

Keizo Yamaguchi, Shuichi Miyazaki, Fusako Kashitani, Morihiro Iwata, Makoto Kanda, Yoshiko Tsujio, Naoki Watanabe, Nobuyuki Uehara, Mitsuomi Kaimori, Chizuko Kawamura, Toshio Nisawataira, Hiromi Tashiro, Kyoko Ueno, Minoru Yasujima, Chuichi Itoh, Takeshi Yoshida, Shunkoh Toyoshima, Jun Katoh, Masako Kudoh, Tadao FunatoMrrsuo Kaku, Nobuko Sato, Yoshihiko Saito, Keiko Ishu, Jun Okada, Yoko Tazawa, Jun Igari, Toyoko Oguri, Yoshitsugu Iinuma, Shiomi Ishigo, Shigeharu Kawahara, Kiyoharu Yamanaka, Toshiharu Matsushima, Yoshihito Niki, Naoyuki Miyashita, Masao Kuwabara, Toshiharu Hongo

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The surveillance study was conducted to determine the antimicrobial activity of fluoroquinolones (ofloxacin, levofloxacin, ciprofloxacin, tosufloxacin) and other 20 antimicrobial agents against 5,180 clinical isolates obtained from 26 medical institutions during 1998 in Japan. The resistance to fluoroquinolones was remarkable in Enterococci, methicillin- resistant stapylococci and Pseudomonas aeruginosa from UTI. However, many of the common pathogens such as Streptococcus pneumoniae including penicillin- resistant isolates, methicillin-susceptible Stahylococcus aureus, Moraxella catarrhalis, the family of Enterobacteriaceae, Haemophilus influenzae including ampicillin-resistant isolates have been kept to be susceptible to fluoroquinolones. About 90% of P. aeruginosa isolates from RTI were susceptible to fluoroquinolones. In conclusion, the results from this surveillance study suggest that fluoroquinolones are useful in the treatment of various bacterial infections including respiratory infections.

Original languageEnglish
Pages (from-to)387-408
Number of pages22
JournalJapanese Journal of Antibiotics
Volume53
Issue number6
Publication statusPublished - 2000 Jun
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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    Yamaguchi, K., Miyazaki, S., Kashitani, F., Iwata, M., Kanda, M., Tsujio, Y., Watanabe, N., Uehara, N., Kaimori, M., Kawamura, C., Nisawataira, T., Tashiro, H., Ueno, K., Yasujima, M., Itoh, C., Yoshida, T., Toyoshima, S., Katoh, J., Kudoh, M., ... Hongo, T. (2000). Activities of antimicrobial agents against 5,180 clinical isolates obtained from 26 medical institutions during 1998 in Japan. Japanese Journal of Antibiotics, 53(6), 387-408.