Activin A-induced apoptosis is suppressed by BCL-2

Takeyoshi Koseki, Kenji Yamato, Stanislaw Krajewski, John C. Reed, Yoshihide Tsujimoto, Tatsuji Nishihara

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Activin A, a member of TGFβ superfamily has various activities including induction of apoptosis in mammalian cells. However, it remains unknown how activin A induces cell death. To clarify this, we investigated the expression of BCL-2 and BAX, and the effect of BCL-2 overexpression on activin A-induced apoptosis in B cell hybridoma cell lines. The activin A-sensitive cell lines expressed BAX but not BCL-2 and that activin A did not increase BAX levels. Overexpression of human BCL-2 suppressed activin A-induced apoptosis in these cells. Thus, activin A has been shown to induce apoptosis by a BCL-2-inhibitable mechanism without activating BAX.

Original languageEnglish
Pages (from-to)247-250
Number of pages4
JournalFEBS Letters
Volume376
Issue number3
DOIs
Publication statusPublished - 1995 Dec 4
Externally publishedYes

Keywords

  • Activin A
  • Apoptosis
  • BAX
  • BCL-2
  • Programmed cell death

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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