Active control by external factors of DNA recognition behavior of α-peptide ribonucleic acids containing basic amino acid residues

Takehiko Wada, Nobuya Sawa, Hirofumi Sato, Mayuko Kikkawa, Keiko Onodera, Seiji Sakamoto, Yoshihisa Inoue

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

A series of novel α-peptide ribonucleic acid (αPRNA) oligomers, possessing alternative αPRNA-Gly/Lys sequences, were newly designed, synthesized, and evaluated as the second- generation PRNA. As expected, the αPRNA with Lys formed stable sequence-specific complex with the complementary DNA, for which both the hydrogen-bonding interactions between, the complementary nucleobase pairs and the electrostatic interactions between the ammonium cation on the lysine side chain and the DNA phosphate anion on the backbone are jointly responsible.

Original languageEnglish
Pages (from-to)112-113
Number of pages2
JournalChemistry Letters
Volume39
Issue number2
DOIs
Publication statusPublished - 2010

ASJC Scopus subject areas

  • Chemistry(all)

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