Active control by external factors of DNA recognition behavior of α-peptide ribonucleic acids containing basic amino acid residues

Takehiko Wada; Nobuya Sawa; Hirofumi Sato; Mayuko Kikkawa; Keiko Onodera; Seiji Sakamoto; Yoshihisa Inoue

doi:10.1246/cl.2010.112

Active control by external factors of DNA recognition behavior of α-peptide ribonucleic acids containing basic amino acid residues

Takehiko Wada, Nobuya Sawa, Hirofumi Sato, Mayuko Kikkawa, Keiko Onodera, Seiji Sakamoto, Yoshihisa Inoue

Division of Organic- and Biomaterials Research

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

A series of novel α-peptide ribonucleic acid (αPRNA) oligomers, possessing alternative αPRNA-Gly/Lys sequences, were newly designed, synthesized, and evaluated as the second- generation PRNA. As expected, the αPRNA with Lys formed stable sequence-specific complex with the complementary DNA, for which both the hydrogen-bonding interactions between, the complementary nucleobase pairs and the electrostatic interactions between the ammonium cation on the lysine side chain and the DNA phosphate anion on the backbone are jointly responsible.

Original language	English
Pages (from-to)	112-113
Number of pages	2
Journal	Chemistry Letters
Volume	39
Issue number	2
DOIs	https://doi.org/10.1246/cl.2010.112
Publication status	Published - 2010

ASJC Scopus subject areas

Chemistry(all)

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10.1246/cl.2010.112

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abstract = "A series of novel α-peptide ribonucleic acid (αPRNA) oligomers, possessing alternative αPRNA-Gly/Lys sequences, were newly designed, synthesized, and evaluated as the second- generation PRNA. As expected, the αPRNA with Lys formed stable sequence-specific complex with the complementary DNA, for which both the hydrogen-bonding interactions between, the complementary nucleobase pairs and the electrostatic interactions between the ammonium cation on the lysine side chain and the DNA phosphate anion on the backbone are jointly responsible.",

author = "Takehiko Wada and Nobuya Sawa and Hirofumi Sato and Mayuko Kikkawa and Keiko Onodera and Seiji Sakamoto and Yoshihisa Inoue",

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T1 - Active control by external factors of DNA recognition behavior of α-peptide ribonucleic acids containing basic amino acid residues

AU - Wada, Takehiko

AU - Sawa, Nobuya

AU - Sato, Hirofumi

AU - Kikkawa, Mayuko

AU - Onodera, Keiko

AU - Sakamoto, Seiji

AU - Inoue, Yoshihisa

PY - 2010

Y1 - 2010

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AB - A series of novel α-peptide ribonucleic acid (αPRNA) oligomers, possessing alternative αPRNA-Gly/Lys sequences, were newly designed, synthesized, and evaluated as the second- generation PRNA. As expected, the αPRNA with Lys formed stable sequence-specific complex with the complementary DNA, for which both the hydrogen-bonding interactions between, the complementary nucleobase pairs and the electrostatic interactions between the ammonium cation on the lysine side chain and the DNA phosphate anion on the backbone are jointly responsible.

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Active control by external factors of DNA recognition behavior of α-peptide ribonucleic acids containing basic amino acid residues

Abstract

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