Active chemotherapy for bone metastasis in sarcomatoid renal cell carcinoma

Senji Hoshi, Makoto Satoh, Chikara Ohyama, Masayoshi Hiramatu, Ryuji Watanabe, Shigeru Hagisawa, Mareyuki Endo, Yoichi Arai

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Sarcomatoid renal cell carcinoma (SRCC) is associated with an aggressive course, high incidence of bone metastasis, and an extremely poor prognosis. There are a few case reports concerning the effectiveness of chemotherapy on metastasis in SRCC. To our knowledge, however, there are no reports describing its effectiveness on bone metastasis. We report a 22-year-old woman with an 8-cm × 7-cm left renal mass. Left nephrectomy was done. The pathological diagnosis was SRCC, INF-β, pT3aN2. Although, she received continuous infusion of interferon α-2a (INFα-2a) and interleukin-2 (IL-2) as adjuvant therapy, liver metastasis appeared 2 months later. Resection of the liver metastasis was done. After resection of the metastasis, multiple bone metastases appeared, in both humeri, the left chest wall, the left fourth rib, and the left iliac bone. The patient was treated with gemcitabine, 1000 mg/m2 (days 1, 8), docetaxel 80 mg/m2 (day 1), and carboplatin 300 mg/m2 (day 1). A computed tomography (CT) scan after the first cycle revealed that the multiple osteolytic bone tumors had significantly decreased in size. Her ability of daily life (ADL) improved and this continued for almost 2 months. A second course of chemotherapy, with gemcitabine and IL-2 was given, but it was ineffective, and the patient died approximately 16 months after the initial diagnosis of SRCC. Combination chemotherapy with gemcitabine, docetaxel, and carboplatin was effective for the bone metastasis of SRCC.

Original languageEnglish
Pages (from-to)113-117
Number of pages5
JournalInternational Journal of Clinical Oncology
Volume8
Issue number2
DOIs
Publication statusPublished - 2003 Apr

Keywords

  • Chemotherapy
  • Docetaxel
  • Gemcitabine
  • Sarcoma
  • Sarcomatoid renal cell carcinoma

ASJC Scopus subject areas

  • Surgery
  • Hematology
  • Oncology

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  • Cite this

    Hoshi, S., Satoh, M., Ohyama, C., Hiramatu, M., Watanabe, R., Hagisawa, S., Endo, M., & Arai, Y. (2003). Active chemotherapy for bone metastasis in sarcomatoid renal cell carcinoma. International Journal of Clinical Oncology, 8(2), 113-117. https://doi.org/10.1007/s101470300020