TY - JOUR
T1 - Active and Inactive Renin after Captopril (SQ 14225) Administration in Hypertensive Patients
AU - Goto, Toshikazu
AU - Abe, Keishi
AU - Otsuka, Yoichi
AU - Seino, Masahide
AU - Ito, Toru
AU - Imai, Yutaka
AU - Haruyama, Toshiaki
AU - Sato, Marito
AU - Hiwatari, Masao
AU - Sato, Ko
AU - Omata, Ken
AU - Kasai, Yutaka
AU - Tajima, Jiro
AU - Yoshinaga, Kaoru
PY - 1983/1
Y1 - 1983/1
N2 - Goto, T., Abe, K., Otsuka, Y., Seino, M., Ito, T., Imai, Y., Haruyama, T., Sato, M., Hiwatari, M., Sato, K., Omata, K., Kasai, Y., Tajima, J. and Yoshinaga, K. Active and Inactive Renin after Captopril (SQ 14225) Administration in Hypertensive Patients. Tohoku J. exp. Med., 1983, 139 (1), 103-111-he changes in active and inactive renin after oral administration of Captopril (SQ 14225) were studied in 29 hypertensive patients. Inactive renin was calculated as plasma renin activity (PRA) after cold storage (total renin) minus PRA before cold storage (active renin). The patients were divided into 2 groups, responders and non-responders, according to the response of active renin to Captopril. In 9 responders, the active renin increased markedly, while the inactive renin decreased. On the other hand, in 20 non-responders, both renin activities increased only slightly. Total renin increased markedly in responders; it increased in much smaller degree but significantly in non-responders. These data suggest that Captopril promotes the conversion of inactive renin to active one and augments the renin release as a whole.-active renin; inactive renin; Captopril.
AB - Goto, T., Abe, K., Otsuka, Y., Seino, M., Ito, T., Imai, Y., Haruyama, T., Sato, M., Hiwatari, M., Sato, K., Omata, K., Kasai, Y., Tajima, J. and Yoshinaga, K. Active and Inactive Renin after Captopril (SQ 14225) Administration in Hypertensive Patients. Tohoku J. exp. Med., 1983, 139 (1), 103-111-he changes in active and inactive renin after oral administration of Captopril (SQ 14225) were studied in 29 hypertensive patients. Inactive renin was calculated as plasma renin activity (PRA) after cold storage (total renin) minus PRA before cold storage (active renin). The patients were divided into 2 groups, responders and non-responders, according to the response of active renin to Captopril. In 9 responders, the active renin increased markedly, while the inactive renin decreased. On the other hand, in 20 non-responders, both renin activities increased only slightly. Total renin increased markedly in responders; it increased in much smaller degree but significantly in non-responders. These data suggest that Captopril promotes the conversion of inactive renin to active one and augments the renin release as a whole.-active renin; inactive renin; Captopril.
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U2 - 10.1620/tjem.139.103
DO - 10.1620/tjem.139.103
M3 - Article
C2 - 6340244
AN - SCOPUS:0020696487
VL - 139
SP - 103
EP - 111
JO - Tohoku Journal of Experimental Medicine
JF - Tohoku Journal of Experimental Medicine
SN - 0040-8727
IS - 1
ER -