Active and Inactive Renin after Captopril (SQ 14225) Administration in Hypertensive Patients

Toshikazu Goto, Keishi Abe, Yoichi Otsuka, Masahide Seino, Toru Ito, Yutaka Imai, Toshiaki Haruyama, Marito Sato, Masao Hiwatari, Ko Sato, Ken Omata, Yutaka Kasai, Jiro Tajima, Kaoru Yoshinaga

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Goto, T., Abe, K., Otsuka, Y., Seino, M., Ito, T., Imai, Y., Haruyama, T., Sato, M., Hiwatari, M., Sato, K., Omata, K., Kasai, Y., Tajima, J. and Yoshinaga, K. Active and Inactive Renin after Captopril (SQ 14225) Administration in Hypertensive Patients. Tohoku J. exp. Med., 1983, 139 (1), 103-111-he changes in active and inactive renin after oral administration of Captopril (SQ 14225) were studied in 29 hypertensive patients. Inactive renin was calculated as plasma renin activity (PRA) after cold storage (total renin) minus PRA before cold storage (active renin). The patients were divided into 2 groups, responders and non-responders, according to the response of active renin to Captopril. In 9 responders, the active renin increased markedly, while the inactive renin decreased. On the other hand, in 20 non-responders, both renin activities increased only slightly. Total renin increased markedly in responders; it increased in much smaller degree but significantly in non-responders. These data suggest that Captopril promotes the conversion of inactive renin to active one and augments the renin release as a whole.-active renin; inactive renin; Captopril.

Original languageEnglish
Pages (from-to)103-111
Number of pages9
Journalthe tohoku journal of experimental medicine
Volume139
Issue number1
DOIs
Publication statusPublished - 1983 Jan

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Active and Inactive Renin after Captopril (SQ 14225) Administration in Hypertensive Patients'. Together they form a unique fingerprint.

Cite this