Activation of the hypothalamic feeding centre upon visual prey detection

Akira Muto, Pradeep Lal, Deepak Ailani, Gembu Abe, Mari Itoh, Koichi Kawakami

    Research output: Contribution to journalArticlepeer-review

    35 Citations (Scopus)

    Abstract

    The visual system plays a major role in food/prey recognition in diurnal animals, and food intake is regulated by the hypothalamus. However, whether and how visual information about prey is conveyed to the hypothalamic feeding centre is largely unknown. Here we perform real-time imaging of neuronal activity in freely behaving or constrained zebrafish larvae and demonstrate that prey or prey-like visual stimuli activate the hypothalamic feeding centre. Furthermore, we identify prey detector neurons in the pretectal area that project to the hypothalamic feeding centre. Ablation of the pretectum completely abolishes prey capture behaviour and neurotoxin expression in the hypothalamic area also reduces feeding. Taken together, these results suggest that the pretecto-hypothalamic pathway plays a crucial role in conveying visual information to the feeding centre. Thus, this pathway possibly converts visual food detection into feeding motivation in zebrafish.

    Original languageEnglish
    Article number15029
    JournalNature communications
    Volume8
    DOIs
    Publication statusPublished - 2017

    ASJC Scopus subject areas

    • Chemistry(all)
    • Biochemistry, Genetics and Molecular Biology(all)
    • Physics and Astronomy(all)

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