Activation of Natural Killer Cells and Dendritic Cells upon Recognition of a Novel CD99-like Ligand by Paired Immunoglobulin-like Type 2 Receptor

Ikuo Shiratori, Kouetsu Ogasawara, Takashi Saito, Lewis L. Lanier, Hisashi Arase

Research output: Contribution to journalArticlepeer-review

100 Citations (Scopus)

Abstract

Paired receptors that consist of highly related activating and inhibitory receptors are widely involved in the regulation of the immune system. Here, we report a mouse orthologue of the human activating paired immunoglobulin-like type 2 receptor (PILR) β, which was cloned from a cDNA library of natural killer (NK) cells based on its ability to associate with the DAP12 signaling adaptor protein. The activating PILRβ was expressed not only on NK cells but also on dendritic cells and macrophages. Furthermore, we have identified a novel CD99-like molecule as a ligand for the activating PILRβ and inhibitory PILRα receptors. Transcripts of PILR ligand are present in many tissues, including some T cell lines. Cells expressing the PILR ligand specifically activated NK cells and dendritic cells that express the activating PILRβ. Our findings reveal a new regulatory mechanism of innate immunity by PILR and its CD99-like ligand.

Original languageEnglish
Pages (from-to)525-533
Number of pages9
JournalJournal of Experimental Medicine
Volume199
Issue number4
DOIs
Publication statusPublished - 2004 Feb 16
Externally publishedYes

Keywords

  • DAP12
  • Immunoglobulin superfamily
  • Innate immunity
  • Natural killer cell receptor
  • Tumor antigen

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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