Activation of GABAA receptor in the brain suppresses neostigmine or histamine-induced central nervous system-mediated hyperglycemia

Katsunori Nonogaki, Li Xianzhu, Kuniaki Ozawa, Hisayuki Miura, Genichi Watanabe, Yasuo Hiyoshi, Tatsuo Tamagawa, Nobuo Sakamoto, Akihisa Iguchi

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

We investigated the effect of GABA receptor agonists on the central nervous system (CNS)-mediated hyperglycemia induced by neostigmine or histamine in anesthetized fed rats. The injection of muscimol, GABAA receptor agonist (1, 2.5 nmol) into the third cerebral ventricle suppressed the hyperglycemia induced by intraventricular injection of neostigmine (1×10-8 mol) or histamine (5×10-7 mol). Baclofen, GABAB receptor agonist (1, 2.5 nmol), however, did not suppress these hyperglycemia. Neither muscimol nor baclofen (2.5 nmol) affected plasma glucose levels. These findings suggest that activation of GABAA receptor in the CNS suppresses the hyperglycemia induced by the stimulation of cholinoceptive neuron or histaminergic neuron, but activation of GABAB receptor does not affect them.

Original languageEnglish
Pages (from-to)PL159-PL163
JournalLife Sciences
Volume53
Issue number9
DOIs
Publication statusPublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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