Activation of extracellular signal-regulated kinase in MDBK cells infected with bovine viral diarrhea virus.

Daisuke Yamane, Muhammad Atif Zahoor, Yassir Mahgoub Mohamed, Walid Azab, Kentaro Kato, Yukinobu Tohya, Hiroomi Akashi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Our efforts to identify the cellular signaling cascades triggered by bovine viral diarrhea virus (BVDV) infection in MDBK cells revealed marked activation of extracellular signal-regulated kinase 1/2 (ERK). Enhanced phosphorylation of ERK was detected following infection with cytopathogenic (cp) BVDV, but not with noncytopathogenic BVDV. It appears that cp BVDV-induced ERK phosphorylation is caused by oxidative stress, because ERK phosphorylation was inducible by treatment with hydrogen peroxide or serum deprivation and was attenuated by addition of antioxidants. These results indicate that BVDV infection influences the ERK signaling pathway via oxidative stress, depending on the biotype.

Original languageEnglish
Pages (from-to)1499-1503
Number of pages5
JournalArchives of virology
Volume154
Issue number9
DOIs
Publication statusPublished - 2009
Externally publishedYes

ASJC Scopus subject areas

  • Virology

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