Activation of complement in human serum by polyurethane having PEO-PTMO-PEO as soft segment

Yuko Ikeda, Shinzo Kohjiya, Shinzo Yamashita, Hiroshi Fukumura

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Complement activation induced by segmented polyurethane and polyurethaneurea was studied. The polymers were synthesized from ABA-type triblock copolyether as a prepolymer, where A represents poly (ethylene oxide) (PEO) and B represents poly (tetramethylene oxide). The PEO contents in the triblock copolyethers were 0, 31 and 62 mol%. The whole complement in serum was activated via the classical and the alternative pathways. The contribution of the fourth complement component (i.e. the classical pathway) became larger with increasing PEO content in the polymers, due to the increased hydrophilicity of the polymer surface. The activation of the alternative pathway was affected by the concentration of NH groups and the degree of swelling of the polymer.

Original languageEnglish
Pages (from-to)110-117
Number of pages8
JournalJournal of Materials Science: Materials in Medicine
Volume2
Issue number2
DOIs
Publication statusPublished - 1991 Apr 1

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Fingerprint

Dive into the research topics of 'Activation of complement in human serum by polyurethane having PEO-PTMO-PEO as soft segment'. Together they form a unique fingerprint.

Cite this