Activation of central GABAA receptors suppresses the alteration of plasma catecholamine levels induced by neostigmine or histamine in rats

Katsunori Nonogaki, Kotomi Mizuno, Nobuo Sakamoto, Akihisa Iguchi

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

We investigated the effects of intraventricular injection of muscimol, the GABAA receptor agonist, on the alteration of plasma epinephrine (E) and norepinephrine (NE) levels induced by neostigmine or histamine in anesthetized rats. Injection of neostigmine (10 nmol) into the third cerebral ventricle increased plasma levels of E more than NE, while histamine (500 nmol) increased plasma levels of NE more than E. Concomitant injection of muscimol (2.5 nmol) with neostigmine or histamine significantly suppressed the alteration of E and NE levels induced by neostigmine or histamine. These findings suggest that activation of central cholinergic neuron stimulates the adrenal medullary response more than the sympathetic nervous system, while activation of central histaminergic neuron stimulates the sympathetic nervous system more than the adrenal medullary response in anesthetized rats. Activation of GABAA receptors in the CNS suppresses these effects.

Original languageEnglish
Pages (from-to)PL409-PL413
JournalLife Sciences
Volume55
Issue number21
DOIs
Publication statusPublished - 1994
Externally publishedYes

Keywords

  • GABA
  • cholinergic
  • epinephrine
  • histamine
  • norepinephrine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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