Activation of ATP receptor increases the cytosolic Ca2+ concentration in ventral tegmental area neurons of rat brain

Masaru Sorimachi; Kazuhiko Yamagami; Minoru Wakomori

doi:10.1016/S0006-8993(02)02473-3

Activation of ATP receptor increases the cytosolic Ca²⁺ concentration in ventral tegmental area neurons of rat brain

Masaru Sorimachi, Kazuhiko Yamagami, Minoru Wakomori

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

ATP increased the cytosolic Ca²⁺ concentration ([Ca]_i) in neurons of ventral tegmental area acutely dissociated from rat brain. The ATP response was dependent on external Ca²⁺ and Na⁺, and was blocked by voltage-dependent Ca²⁺ channel blockers. The results suggest that the ATP-induced depolarization increases Ca²⁺ influx via voltage-gated Ca²⁺ channels resulting in the increase in [Ca]_i.

Original language	English
Pages (from-to)	129-133
Number of pages	5
Journal	Brain research
Volume	935
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(02)02473-3
Publication status	Published - 2002 May 10
Externally published	Yes

Keywords

ATP
Ca channel
Fura-2 microfluorometry
Purinoceptor
Ventral tegmental area

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/S0006-8993(02)02473-3

Cite this

@article{be2ebc25f4294cb9afd49267cbaec1d4,

title = "Activation of ATP receptor increases the cytosolic Ca2+ concentration in ventral tegmental area neurons of rat brain",

abstract = "ATP increased the cytosolic Ca2+ concentration ([Ca]i) in neurons of ventral tegmental area acutely dissociated from rat brain. The ATP response was dependent on external Ca2+ and Na+, and was blocked by voltage-dependent Ca2+ channel blockers. The results suggest that the ATP-induced depolarization increases Ca2+ influx via voltage-gated Ca2+ channels resulting in the increase in [Ca]i.",

keywords = "ATP, Ca channel, Fura-2 microfluorometry, Purinoceptor, Ventral tegmental area",

author = "Masaru Sorimachi and Kazuhiko Yamagami and Minoru Wakomori",

year = "2002",

month = may,

day = "10",

doi = "10.1016/S0006-8993(02)02473-3",

language = "English",

volume = "935",

pages = "129--133",

journal = "Molecular Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - Activation of ATP receptor increases the cytosolic Ca2+ concentration in ventral tegmental area neurons of rat brain

AU - Sorimachi, Masaru

AU - Yamagami, Kazuhiko

AU - Wakomori, Minoru

PY - 2002/5/10

Y1 - 2002/5/10

N2 - ATP increased the cytosolic Ca2+ concentration ([Ca]i) in neurons of ventral tegmental area acutely dissociated from rat brain. The ATP response was dependent on external Ca2+ and Na+, and was blocked by voltage-dependent Ca2+ channel blockers. The results suggest that the ATP-induced depolarization increases Ca2+ influx via voltage-gated Ca2+ channels resulting in the increase in [Ca]i.

AB - ATP increased the cytosolic Ca2+ concentration ([Ca]i) in neurons of ventral tegmental area acutely dissociated from rat brain. The ATP response was dependent on external Ca2+ and Na+, and was blocked by voltage-dependent Ca2+ channel blockers. The results suggest that the ATP-induced depolarization increases Ca2+ influx via voltage-gated Ca2+ channels resulting in the increase in [Ca]i.

KW - ATP

KW - Ca channel

KW - Fura-2 microfluorometry

KW - Purinoceptor

KW - Ventral tegmental area

UR - http://www.scopus.com/inward/record.url?scp=0037052621&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037052621&partnerID=8YFLogxK

U2 - 10.1016/S0006-8993(02)02473-3

DO - 10.1016/S0006-8993(02)02473-3

M3 - Article

C2 - 12062483

AN - SCOPUS:0037052621

SN - 0006-8993

VL - 935

SP - 129

EP - 133

JO - Molecular Brain Research

JF - Molecular Brain Research

IS - 1-2

ER -