Action of 6-amino-3-pyridinols as novel antioxidants against free radicals and oxidative stress in solution, plasma, and cultured cells

Yo Omata, Yoshiro Saito, Yasukazu Yoshida, Byeong Seon Jeong, Remigiusz Serwa, Tae gyu Nam, Ned A. Porter, Etsuo Niki

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Free radical-mediated lipid peroxidation has been implicated in the pathogenesis of various diseases. Lipid peroxidation products are cytotoxic and they modify proteins and DNA bases, leading eventually to degenerative disorders. Various synthetic antioxidants have been developed and assessed for their capacity to inhibit lipid peroxidation and oxidative stress induced by free radicals. In this study, the capacity of novel 6-amino-2,4,5-trimethyl-3-pyridinols for scavenging peroxyl radicals, inhibiting plasma lipid peroxidation in vitro, and preventing cytotoxicity induced by glutamate, 6-hydroxydopamine, 1-methyl-4-phenylpyridium (MPP+ ), and hydroperoxyoctadecadienoic acid was assessed. It was found that they exerted higher reactivity toward peroxyl radicals and more potent activity for inhibiting the above oxidative stress than α-tocopherol, the most potent natural antioxidant, except against the cytotoxicity induced by MPP+. These results suggest that the novel 6-amino-3-pyridinols may be potent antioxidants against oxidative stress.

Original languageEnglish
Pages (from-to)1358-1365
Number of pages8
JournalFree Radical Biology and Medicine
Volume48
Issue number10
DOIs
Publication statusPublished - 2010 May 1
Externally publishedYes

Keywords

  • Amino-3-pyridinols
  • Antioxidant
  • Cytotoxicity
  • Free radical
  • Lipid peroxidation

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

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