Abstract
We report a case of acrokeratosis paraneoplastica (AP; Bazex syndrome), characterized by typical palmoplantar hyperkeratosis and psoriasiform scaly erythema of the acral regions, associated with primary cutaneous squamous cell carcinoma (SCC) on the left lower leg. This 54-year-old Japanese man subsequently developed vitiligo, and alopecia areata of the scalp. Serial monitoring of squamous cell carcinoma antigen (SCC-Ag) demonstrated that the severity of the clinical manifestations of AP paralleled the serum concentrations of SCC-Ag. We suggest that an immune-mediated mechanism underlies the development of AP in this patient.
Original language | English |
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Pages (from-to) | 121-124 |
Number of pages | 4 |
Journal | British Journal of Dermatology |
Volume | 133 |
Issue number | 1 |
Publication status | Published - 1995 Jan 1 |
ASJC Scopus subject areas
- Dermatology