Acrokeratosis paraneoplastica (Bazex syndrome) associated with primary cutaneous squamous cell carcinoma of the lower leg, vitiligo and alopecia areata

M. Hara; M. Hunayama; S. Aiba; T. Suetake; M. Watanabe; M. Tanaka; H. Tagami

Acrokeratosis paraneoplastica (Bazex syndrome) associated with primary cutaneous squamous cell carcinoma of the lower leg, vitiligo and alopecia areata

M. Hara, M. Hunayama, S. Aiba, T. Suetake, M. Watanabe, M. Tanaka, H. Tagami

Research output: Contribution to journal › Article › peer-review

Abstract

We report a case of acrokeratosis paraneoplastica (AP; Bazex syndrome), characterized by typical palmoplantar hyperkeratosis and psoriasiform scaly erythema of the acral regions, associated with primary cutaneous squamous cell carcinoma (SCC) on the left lower leg. This 54-year-old Japanese man subsequently developed vitiligo, and alopecia areata of the scalp. Serial monitoring of squamous cell carcinoma antigen (SCC-Ag) demonstrated that the severity of the clinical manifestations of AP paralleled the serum concentrations of SCC-Ag. We suggest that an immune-mediated mechanism underlies the development of AP in this patient.

Original language	English
Pages (from-to)	121-124
Number of pages	4
Journal	British Journal of Dermatology
Volume	133
Issue number	1
Publication status	Published - 1995 Jan 1

ASJC Scopus subject areas

Dermatology

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Acrokeratosis paraneoplastica (Bazex syndrome) associated with primary cutaneous squamous cell carcinoma of the lower leg, vitiligo and alopecia areata. / Hara, M.; Hunayama, M.; Aiba, S.; Suetake, T.; Watanabe, M.; Tanaka, M.; Tagami, H.

In: British Journal of Dermatology, Vol. 133, No. 1, 01.01.1995, p. 121-124.

Research output: Contribution to journal › Article › peer-review

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Acrokeratosis paraneoplastica (Bazex syndrome) associated with primary cutaneous squamous cell carcinoma of the lower leg, vitiligo and alopecia areata

Abstract

ASJC Scopus subject areas

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