Acrokeratosis paraneoplastica (Bazex syndrome) associated with primary cutaneous squamous cell carcinoma of the lower leg, vitiligo and alopecia areata

M. Hara, M. Hunayama, S. Aiba, T. Suetake, M. Watanabe, M. Tanaka, H. Tagami

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33 Citations (Scopus)

Abstract

We report a case of acrokeratosis paraneoplastica (AP; Bazex syndrome), characterized by typical palmoplantar hyperkeratosis and psoriasiform scaly erythema of the acral regions, associated with primary cutaneous squamous cell carcinoma (SCC) on the left lower leg. This 54-year-old Japanese man subsequently developed vitiligo, and alopecia areata of the scalp. Serial monitoring of squamous cell carcinoma antigen (SCC-Ag) demonstrated that the severity of the clinical manifestations of AP paralleled the serum concentrations of SCC-Ag. We suggest that an immune-mediated mechanism underlies the development of AP in this patient.

Original languageEnglish
Pages (from-to)121-124
Number of pages4
JournalBritish Journal of Dermatology
Volume133
Issue number1
Publication statusPublished - 1995 Jan 1

ASJC Scopus subject areas

  • Dermatology

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