Acetylsalicylic acid reduces ischemia-induced proliferation of dentate cells in gerbils

Kentarou Kumihashi, Katsuya Uchida, Hidetaka Miyazaki, Junji Kobayashi, Takashi Tsushima, Takeo Machida

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

Transient global ischemia causes neurogenesis in the dentate gyrus of adult rodents. Ischemic insults to rodents also induce cyclooxygenase-2 (COX-2), an isoform of cyclooxygenases (COXs) and a rate-limiting enzyme for prostanoid synthesis. In the present experiments, adult Mongolian gerbils were chronically treated with acetylsalicylic acid (ASA), a non-selective COX inhibitor, and the proliferation of cells in the dentate gyrus was examined under ischemia. It was proved that BrdUlabeled cells in the dentate gyrus were significantly reduced in number following ASA treatment after 10 min global ischemia. The result strongly suggests that COX, probably COX-2, and prostanoids play an important role in the proliferation of neural cells after ischemia in gerbils.

Original languageEnglish
Pages (from-to)915-917
Number of pages3
JournalNeuroReport
Volume12
Issue number5
DOIs
Publication statusPublished - 2001 Apr 17
Externally publishedYes

Keywords

  • Acetylsalicylic acid
  • Cell proliferation
  • Cyclooxygenase
  • Dentate gyrus
  • Ischemia

ASJC Scopus subject areas

  • Neuroscience(all)

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