Acetic acid promoted metal-free aerobic carbon-carbon bond forming reactions at α-position of tertiary amines

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Abstract

The oxidative functionalization of the benzylic C-H bonds in tetrahydroisoquinolines and tetrahydro-β-carboline derivatives was investigated. C-C bond forming reactions proceeded with a range of nucleophiles (nitroalkane, enol silyl ether, indole, allylstannane, and tetrabutylammonium cyanide) under metal-free conditions and an oxygen atmosphere. Acetic acid caused a significant acceleration effect.

Original languageEnglish
Pages (from-to)4194-4197
Number of pages4
JournalOrganic letters
Volume16
Issue number16
DOIs
Publication statusPublished - 2014 Aug 15

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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