Accurate characterization of pure silicon-substituted hydroxyapatite powders synthesized by a new precipitation route

David Marchat, Maria Zymelka, Cristina Coelho, Laurent Gremillard, Lucile Joly-Pottuz, Florence Babonneau, Claude Esnouf, Jérôme Chevalier, Didier Bernache-Assollant

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

This paper presents a new aqueous precipitation method to prepare silicon-substituted hydroxyapatites Ca10(PO4) 6-y(SiO4)y(OH)2- y(VOH)y (SiHAs) and details the characterization of powders with varying Si content up to y = 1.25 mol mol SiHA-1. X-ray diffraction, transmission electron microscopy, solid-state nuclear magnetic resonance and Fourier transform infrared spectroscopy were used to accurately characterize samples calcined at 400 C for 2 h and 1000 C for 15 h. This method allows the synthesis of monophasic SiHAs with controlled stoichiometry. The theoretical maximum limit of incorporation of Si into the hexagonal apatitic structure is y < 1.5. This limit depends on the OH content in the channel, which is a function of the Si content, temperature and atmosphere of calcination. These results, particularly those from infrared spectroscopy, raise serious reservations about the phase purity of previously prepared and biologically evaluated SiHA powders, pellets and scaffolds in the literature.

Original languageEnglish
Pages (from-to)6992-7004
Number of pages13
JournalActa Biomaterialia
Volume9
Issue number6
DOIs
Publication statusPublished - 2013 Jun

Keywords

  • Biomaterials
  • Infrared spectroscopy
  • NMR spectroscopy
  • Precipitation
  • Silicon-substituted hydroxyapatite

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

Fingerprint Dive into the research topics of 'Accurate characterization of pure silicon-substituted hydroxyapatite powders synthesized by a new precipitation route'. Together they form a unique fingerprint.

  • Cite this

    Marchat, D., Zymelka, M., Coelho, C., Gremillard, L., Joly-Pottuz, L., Babonneau, F., Esnouf, C., Chevalier, J., & Bernache-Assollant, D. (2013). Accurate characterization of pure silicon-substituted hydroxyapatite powders synthesized by a new precipitation route. Acta Biomaterialia, 9(6), 6992-7004. https://doi.org/10.1016/j.actbio.2013.03.011