Accumulation of plasma cells in atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits

Yoshiaki Sohma, Hironobu Sasano, Ryoko Shiga, Shigeru Saeki, Takashi Suzuki, Hiroshi Nagura, Masato Nose, Tokuo Yamamoto

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

By screening a cDNA library constructed from aortic total RNA derived ham Watanabe heritable hyperlipidemic (WHHL) rabbits by differential hybridization, we have obtained a cDNA encoding the κ light chain of immunoglobulin. Northern blot analysis of total RNA prepared from aortas of WHHL and normal rabbits of various ages revealed that this light-chain mRNA accumulates gradually with age in aortas in WHHL rabbits. Northern blotting and in situ hybridization with an antisense oligonucleotide specific to rabbit immunoglobulin γ heavy-chain mRNA also detected accumulation of this heavy-chain mRNA in advanced lesions of WHHL rabbit aortas. Moreover, immunohistochemical and electron microscopic analyses demonstrated the presence of plasma cells in the atherosclerotic lesions.

Original languageEnglish
Pages (from-to)4937-4941
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume92
Issue number11
DOIs
Publication statusPublished - 1995 May 23

Keywords

  • IgG
  • low density lipoprotein receptor deficient

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Accumulation of plasma cells in atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits'. Together they form a unique fingerprint.

  • Cite this