Acceleration of UVB-induced photoageing in nrf2 gene-deficient mice

Ayako Hirota, Yasuhiro Kawachi, Masayuki Yamamoto, Tsutomu Koga, Kazuhiko Hamada, Fujio Otsuka

Research output: Contribution to journalArticlepeer-review

60 Citations (Scopus)

Abstract

Ultraviolet (UV) radiation is one of the most important environmental factors involved in the pathogenesis of premature skin ageing, termed photoageing. The harmful effects of UV in photoageing are associated with the generation of reactive oxygen species, and cellular antioxidants act to prevent the occurrence and reduce the severity of UV-induced photoageing. The transcription factor Nrf2 and its cytoplasmic anchor protein, Keap1, are central regulators of the cellular antioxidant response. Here, we investigated the role of the Nrf2-Keap1 pathway in photoageing using nrf2 gene-deficient (nrf2 -/-) mice. Our results indicated that UVB-irradiated nrf2 -/- mice showed accelerated photoageing, such as coarse wrinkle formation, loss of skin flexibility, epidermal thickening and deposition of extracellular matrix in the upper dermis. In addition, nrf2 -/- mice also showed an increase in cutaneous reactivity for the lipid peroxidation product 4-hydroxy-2-nonenal and a significant decrease in cutaneous glutathione level. These findings indicate that Nrf2 plays the important role in the protection against UVB-induced photoageing.

Original languageEnglish
Pages (from-to)664-668
Number of pages5
JournalExperimental Dermatology
Volume20
Issue number8
DOIs
Publication statusPublished - 2011 Aug

Keywords

  • Nrf2
  • Photoageing
  • Reactive oxygen species

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

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