Acceleration of astrocytic differentiation in neural stem cells surviving X-irradiation

Ayumi Ozeki, Keiji Suzuki, Masatoshi Suzuki, Hiroki Ozawa, Shunichi Yamashita

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Neural stem cells (NSCs) are highly susceptible to DNA double-strand breaks; however, little is known about the effects of radiation in cells surviving radiation. Although the nestin-positive NSCs predominantly became glial fibrillary acidic protein (GFAP)-positive in differentiation-permissive medium, little or no cells were GFAP positive in proliferation-permissive medium. We found that more than half of the cells surviving X-rays became GFAP positive in proliferation-permissive medium. Moreover, localized irradiation stimulated differentiation of cells outside the irradiated area. These results indicate for the first time that ionizing radiation is able to stimulate astrocyte-specific differentiation of surviving NSCs, whose process is mediated both by the direct activation of nuclear factor-jB and by the indirect bystander effect induced by X-irradiation.

Original languageEnglish
Pages (from-to)290-293
Number of pages4
Issue number5
Publication statusPublished - 2012 Mar 28
Externally publishedYes


  • Bystander signal
  • Glial fibrillary acidic protein
  • Nuclear factor-jB
  • X-ray

ASJC Scopus subject areas

  • Neuroscience(all)


Dive into the research topics of 'Acceleration of astrocytic differentiation in neural stem cells surviving X-irradiation'. Together they form a unique fingerprint.

Cite this