Accelerated memory decline in Alzheimer's disease with apolipoprotein ε4 allele

Nobutsugu Hirono, Mamoru Hashimoto, Minoru Yasuda, Hirokazu Kazui, Etsuro Mori

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)


To investigate a possible effect of the apolipoprotein (APOE) ε4 allele on memory decline in Alzheimer's disease (AD), we examined 64 AD patients with the APOE ε3/3, ε3/4, or ε4/4 allele using the Alzheimer Disease Assessment Scale-Cognitive subscale (ADAS-Cog) and its subtests at the initial examination and at the 1-year follow-up visit. One-year changes in the scores of the Word Recall subtest, Word Recognition subtest, and total ADAS-Cog were significantly correlated with the number of APOE ε4 alleles after controlling for the effects of age, sex, education, test interval, and baseline scores. Findings revealed that APOE ε4 allele is related to an accelerated memory decline in AD.

Original languageEnglish
Pages (from-to)354-358
Number of pages5
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number3
Publication statusPublished - 2003 Jan 1

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


Dive into the research topics of 'Accelerated memory decline in Alzheimer's disease with apolipoprotein ε4 allele'. Together they form a unique fingerprint.

Cite this