Abstract
Since E-selectin-mediated adhesion of leukocytes or tumor cells to the vascular endothelium is a key early event in the initiation of inflammatory response and cancer metastasis, E-selectin inhibition is thought to be a good target for therapeutic intervention. Several flavones have been shown to have anti-inflammatory and anticancer properties. In the present study, we investigated the effects of plant flavones on expression of E-selectin in human umbilical vein endothelial cells. Among 11 flavones, acacetin strongly inhibited TNF-α-induced E-selectin expression in HUVECs. Acacetin suppressed the TNF-α-induced phosphorylation of p38 but did not inhibit TNF-α-induced phosphorylations of JNK and ERK. Acacetin also inhibited the activation of NF-κB by stimulation with TNF-α. Furthermore, adhesion of monocytes to TNF-α-treated endothelial cells was inhibited by cotreatment with acacetin. These results suggest that acacetin inhibits the expression of E-selectin by regulation of the p38 MAPK signaling pathway and activation of NF-κB.
Original language | English |
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Pages (from-to) | 471-477 |
Number of pages | 7 |
Journal | Immunopharmacology and Immunotoxicology |
Volume | 35 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2013 Aug |
Externally published | Yes |
Keywords
- Adhesion molecules
- Flavones
- Immunomodulation
- Supplement
- Vascular inflammation
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Toxicology
- Pharmacology