Absorption of methylmercury compounds from rat intestine

Urano Tsutomu, Iwasaki Akiko, Himeno Sei-ichiro, Naganuma Akira, Imura Nobumasa

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Intestinal absorption of methylmercury complexed with non-protein sulfhydryl compounds (NPSHs) as occurs in bile was studied by means of direct injection of mercury compounds into ligated intestinal segments of rats. The extent of absorption of methylmercury-cysteinylglycine (MM-CysGly) was similar to that of methylmercury-cysteine (MM-Cys) and 1.5 times larger than that of methylmercury-glutathione (MM-GSH). This result suggested that MM-CysGly, which is recognized as a major component of methylmercury in rat bile, can be easily reabsorbed from the intestine. These results indicate that not only MM-GSH and MM-Cys but also MM-CysGly may play important roles in the intestinal reabsorption of methylmercury during its enterohepatic circulation. When the ligated intestine was pretreated with probenecid and acivicin, the intestinal absorption of MM-GSH was depressed much more than in the case of treatment with acivicin alone. This indicates the possibility that there are at least two systems for intestinal transport of MM-GSH i.e. γ-glutamyltrans-peptidase (GGT)-dependent and -independent systems.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalToxicology Letters
Volume50
Issue number2-3
DOIs
Publication statusPublished - 1990 Feb

Keywords

  • Enterohepatic circulation
  • Intestinal absorption
  • Methylmercury
  • Sulfhydryl compounds

ASJC Scopus subject areas

  • Toxicology

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