Absorption and transport of base moieties of phosphatidylcholine and phosphatidylethanolamine in rats

Ikeda Ikuo, Imaizumi Katsumi, Sugano Michihiro

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34 Citations (Scopus)


The absorption and transport of the base moieties of phosphatidylethanolamine (PE) and phosphatidylcholine (PC) which were fed to rats were compared. The major absorption site of ethanolamine-labeled PE was proximal jejunum while choline-labeled PC was absorbed almost equally throughout the jejunum. Lysophospholipids, glycerophosphoryl bases and constituent bases were the main digested products in intestinal content. This shows that base-labeled phospholipids were hydrolyzed to water-soluble products as well as lysophospholipids before absorption. The radioactivities from both phospholipids existed mainly in their parent phospholipids and water-soluble products in the intestinal mucosa. The amounts of lymphatic transport of the radioactivities from choline-labeled PC and ethanolamine-labeled PE were 17% and 8%, respectively, at 8 h after administration. The liver in lymph-cannulated rats contained 23% and 48% radioactivity from PC and PE, respectively, suggesting that base moieties of phospholipids, especially PE, were transported mainly via a non-lymphatic route, probably the portal vein, to the liver, as water-soluble products. The radioactivity from both base-labeled phospholipids in the liver was distributed in the parent phospholipids and water-soluble fractions. Ethanolamine-labeled PE was also incorporated into PC in the liver. These results indicate that intestinal absorption and transport of the base moiety of dietary PC and PE are similar; however, their intestinal absorption site and the extent of their separation during transport between the lymphatic and portal systems differ markedly.

Original languageEnglish
Pages (from-to)245-253
Number of pages9
JournalBiochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Issue number2
Publication statusPublished - 1987 Sep 25
Externally publishedYes


  • (Rat intestine)
  • Phosphatidylcholine
  • Phosphatidylethanolamine
  • Phospholipid absorption

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Endocrinology


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