Absorption and effectiveness of orally administered low molecular weight collagen hydrolysate in rats

Watanabe Kamiyama Mari, Shimizu Muneshige, Kamiyama Shin, Taguchi Yasuki, Sone Hideyuki, Morimatsu Fumiki, Shirakawa Hitoshi, Furukawa Yuji, Komai Michio

Research output: Contribution to journalArticlepeer-review

100 Citations (Scopus)


Collagen, a major extracellular matrix macromolecule, is widely used for biomedical purposes. We investigated the absorption mechanism of low molecular weight collagen hydrolysate (LMW-CH) and its effects on osteoporosis in rats. When administered to Wistar rats with either [14C]proline (Pro group) or glycyl-[14C]prolyl-hydroxyproline (CTp group), LMW-CH rapidly increased plasma radioactivity. LMW-CH was absorbed into the blood of Wistar rats in the peptide form. Glycyl-prolylhydroxyproline tripeptide remained in the plasma and accumulated in the kidney. In both groups, radioactivity was retained at a high level in the skin until 14 days after administration. Additionally, the administration of LMW-CH to ovariectomized stroke-prone spontaneously hypertensive rats increased the organic substance content and decreased the water content of the left femur. Our findings show that LMW-CH exerts a beneficial effect on osteoporosis by increasing the organic substance content of bone.

Original languageEnglish
Pages (from-to)835-841
Number of pages7
JournalJournal of Agricultural and Food Chemistry
Issue number2
Publication statusPublished - 2010 Jan 27


  • Absorption; collagen tripeptide; low molecular weight collagen hydrolysate; osteoporosis; OVX; SHRSP

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)


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