TY - JOUR
T1 - Absorbed Dose Estimates in Positron Emission Tomography Studies Based on the Administration of 18F-Labeled Radiopharmaceuticals
AU - Mejia, Alvaro A.
AU - Nakamura, Takashi
AU - Itoh, Masatoshi
AU - Hatazawa, Jun
AU - Ishiwata, Kiichi
AU - Ido, Tatsuo
AU - Matsumoto, Masaki
AU - Watabe, Hiroshi
AU - Watanuki, Shoichi
AU - Sec, Shinya
PY - 1991
Y1 - 1991
N2 - Absorbed doses were estimated after intravenous administration of 18F-labeled radiopharmaceuticals in Positron Emission Tomography (PET) studies. These radiopharmaceuticals; [,8F]-2-Fiuoro-2-Deoxy-D-Glucose (FDG), 6-[18F]Fluoro-L-Dopa (FDOPA) and ,8F-5-Fluorodcoxyuridine (FdUR), are used in clinical research at the Cyclotron and Radioisotope Center of Tohoku University. Radiopharmaceutical biokinetic values were measured in humans or extrapolated from animal experiments. Selective organ uptake and rapid clearance of activity from the blood were observed. High activity in the bladder contents of humans was found. Calculations were made by the MIRD method, modified to account for the differences in physique and organ mass between the Caucasian Reference Man and the Japanese one. The bladder wall receives the highest dose (more than 1.23x10 1 mGy/MBq) when any of these compounds arc administered. Other organs receiving high doses are the heart, brain and kidneys from FDG; the kidneys and pancreas from FDOPA, and the kidneys and small intestine from FdUR. These organs received absorbed doses of more than 2.7x10“ 2 mGy/MBq. Effective dose equivalents of 2.4xl0”2, 2.6xl0~2 and 3.3xl0-2 mSv/MBq were estimated in the intravenous administration of l8F-FDG, 1KF-FDOPA and !8F-FdUR, respectively.
AB - Absorbed doses were estimated after intravenous administration of 18F-labeled radiopharmaceuticals in Positron Emission Tomography (PET) studies. These radiopharmaceuticals; [,8F]-2-Fiuoro-2-Deoxy-D-Glucose (FDG), 6-[18F]Fluoro-L-Dopa (FDOPA) and ,8F-5-Fluorodcoxyuridine (FdUR), are used in clinical research at the Cyclotron and Radioisotope Center of Tohoku University. Radiopharmaceutical biokinetic values were measured in humans or extrapolated from animal experiments. Selective organ uptake and rapid clearance of activity from the blood were observed. High activity in the bladder contents of humans was found. Calculations were made by the MIRD method, modified to account for the differences in physique and organ mass between the Caucasian Reference Man and the Japanese one. The bladder wall receives the highest dose (more than 1.23x10 1 mGy/MBq) when any of these compounds arc administered. Other organs receiving high doses are the heart, brain and kidneys from FDG; the kidneys and pancreas from FDOPA, and the kidneys and small intestine from FdUR. These organs received absorbed doses of more than 2.7x10“ 2 mGy/MBq. Effective dose equivalents of 2.4xl0”2, 2.6xl0~2 and 3.3xl0-2 mSv/MBq were estimated in the intravenous administration of l8F-FDG, 1KF-FDOPA and !8F-FdUR, respectively.
KW - Fluorine eighteen
KW - Positron Emission Tomography/Japanese physique
KW - Radiopharmaceuticals/Radiation
KW - absorbed dose
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U2 - 10.1269/jrr.32.243
DO - 10.1269/jrr.32.243
M3 - Article
C2 - 1838773
AN - SCOPUS:0026216796
VL - 32
SP - 243
EP - 261
JO - Journal of Radiation Research
JF - Journal of Radiation Research
SN - 0449-3060
IS - 3
ER -