Absorbed Dose Estimates in Positron Emission Tomography Studies Based on the Administration of 18F-Labeled Radiopharmaceuticals

Alvaro A. Mejia, Takashi Nakamura, Masatoshi Itoh, Jun Hatazawa, Kiichi Ishiwata, Tatsuo Ido, Masaki Matsumoto, Hiroshi Watabe, Shoichi Watanuki, Shinya Sec

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Absorbed doses were estimated after intravenous administration of 18F-labeled radiopharmaceuticals in Positron Emission Tomography (PET) studies. These radiopharmaceuticals; [,8F]-2-Fiuoro-2-Deoxy-D-Glucose (FDG), 6-[18F]Fluoro-L-Dopa (FDOPA) and ,8F-5-Fluorodcoxyuridine (FdUR), are used in clinical research at the Cyclotron and Radioisotope Center of Tohoku University. Radiopharmaceutical biokinetic values were measured in humans or extrapolated from animal experiments. Selective organ uptake and rapid clearance of activity from the blood were observed. High activity in the bladder contents of humans was found. Calculations were made by the MIRD method, modified to account for the differences in physique and organ mass between the Caucasian Reference Man and the Japanese one. The bladder wall receives the highest dose (more than 1.23x10 1 mGy/MBq) when any of these compounds arc administered. Other organs receiving high doses are the heart, brain and kidneys from FDG; the kidneys and pancreas from FDOPA, and the kidneys and small intestine from FdUR. These organs received absorbed doses of more than 2.7x10“ 2 mGy/MBq. Effective dose equivalents of 2.4xl0”2, 2.6xl0~2 and 3.3xl0-2 mSv/MBq were estimated in the intravenous administration of l8F-FDG, 1KF-FDOPA and !8F-FdUR, respectively.

Original languageEnglish
Pages (from-to)243-261
Number of pages19
JournalJournal of radiation research
Volume32
Issue number3
DOIs
Publication statusPublished - 1991

Keywords

  • Fluorine eighteen
  • Positron Emission Tomography/Japanese physique
  • Radiopharmaceuticals/Radiation
  • absorbed dose

ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Health, Toxicology and Mutagenesis

Fingerprint Dive into the research topics of 'Absorbed Dose Estimates in Positron Emission Tomography Studies Based on the Administration of <sup>18</sup>F-Labeled Radiopharmaceuticals'. Together they form a unique fingerprint.

Cite this