A new chaetochiversin analog, designated chaetochiversin C (1), was discovered from a cul-tured broth of fungal strain FKI-7792 by physico-chemical screening. This strain was identified as a member of genus Neocosmospora based on mor-phology and DNA barcoding. The partially relative configuration of 1 was determined by13C-NMR chemical shifts of the acetonide analog of 1. The absolute configuration was determined using an advanced Mosher’s method. Compound 1 was as-sessed for anti-tumor, anti-microbial, and anti-malarial activities, and its ability to scavenge or quench reactive oxygen species (ROS), such as superoxide anion radicals, hydroxy radicals and singlet oxygen (1O2 ). Compound 1 showed a quenching effect on1O2.
- Absolute structure
- Chaetochiversin analog
- Physico-chemical screening
ASJC Scopus subject areas
- Applied Microbiology and Biotechnology