Absence of p51 mutation in human hepatocellular carcinoma

Kunihiro Hamada, Toru Koyama, Kimihiro Shimizu, Shuntaro Ikawa, Susumu Kawate, Jun Yokota, Susumu Ohwada, Yasuo Morishita

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The p51 gene encodes a protein with significant homology to p53. To investigate the involvement of the p51 gene in human hepatocarcinogenesis, mutation analysis of the p51 gene was performed in 54 cases of hepatocellular carcinoma (HCC). No mutations causing amino acid substitutions or frameshifts were found by polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) analysis of the entire coding region. The result indicated that mutation of the p51 gene does not play a major role in the development of HCC in Japanese patients. Further studies on p51 expression and its functions, including the interaction with p53, are necessary to elucidate the role of the p51 gene in human hepatocarcinogenesis.

Original languageEnglish
Pages (from-to)161-164
Number of pages4
JournalCancer Letters
Volume148
Issue number2
DOIs
Publication statusPublished - 2000 Feb 1
Externally publishedYes

Keywords

  • Hepatocellular carcinoma
  • Mutation
  • p51 gene
  • p53 family

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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