Absence of IgG1 response in the cerebrospinal fluid of relapsing neuromyelitis optica

Ichiro Nakashima, Kazuo Fujihara, J. Fujimori, K. Narikawa, T. Misu, Y. Itoyama

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

The authors studied immunoglobulin (Ig) G subclasses in the CSF and sera of patients with relapsing neuromyelitis optica (RNMO) and typical multiple sclerosis (MS). Although the total IgG concentrations were elevated in the CSF of patients with RNMO and MS, IgG1% and IgG1 index were significantly elevated only in patients with MS. The absence of the CSF IgG1 responses in the patients with RNMO may suggest less Thl immunity and may also explain the rarity of oligoclonal IgG bands in patients with this disease.

Original languageEnglish
Pages (from-to)144-146
Number of pages3
JournalNeurology
Volume62
Issue number1
DOIs
Publication statusPublished - 2004 Jan 13

ASJC Scopus subject areas

  • Clinical Neurology

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