Abortive oncogeny and cell cycle-mediated events in Alzheimer disease.

A. K. Raina, X. Zhu, M. Monteiro, A. Takeda, M. A. Smith

Research output: Contribution to journalReview articlepeer-review

30 Citations (Scopus)


Alzheimer disease, the leading cause of senile dementia, is characterised by the degeneration of select neuronal populations. While the mechanism(s) underlying such cell loss are largely unknown, recent findings indicate inappropriate re-entry into the cell cycle resembling an abortive oncogeny. In postmitotic neurons, such mitotic re-entrance is deleterious and one that involves virtually the entire spectrum of the described pathological events in Alzheimer disease including, ultimately, cell death.

Original languageEnglish
Pages (from-to)235-242
Number of pages8
JournalProgress in cell cycle research
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Medicine(all)


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