Abnormalities in aggression and anxiety in transgenic mice overexpressing activin E

Kazunari Sekiyama; Osamu Hashimoto; Yuuki Ushiro; Chika Adachi; Takefumi Kikusui; Kentaro Tanemura; Yoshihisa Hasegawa

doi:10.1016/j.bbrc.2009.05.054

Abnormalities in aggression and anxiety in transgenic mice overexpressing activin E

Kazunari Sekiyama, Osamu Hashimoto, Yuuki Ushiro, Chika Adachi, Takefumi Kikusui, Kentaro Tanemura, Yoshihisa Hasegawa

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

To study the function of activin E, a TGF-β superfamily member, in the regulation of affective behavior, we investigated the behavior of transgenic mice overexpressing activin E (TgActβE mice). Male TgActβE mice showed aggressive behavior in resident-intruder tests. In elevated plus-maze tests, the percentage of open arm entries was significantly increased in female TgActβE mice compared with that in wild-type mice. Furthermore, female TgActβE mice stayed in the central area for a significantly longer time than wild-type mice in open field tests. These results indicated that TgActβE mice had less anxiety-like behavior. The number of restraint-stress-evoked c-Fos-positive cells in the hypothalamic paraventricular nucleus in TgActβE mice was significantly decreased compared with that in wild-type mice. This suggests that synthesis of corticotrophin-releasing hormone induced by stress was decreased in TgActβE mice. Taking these results together, activin E may act as a regulator of the hypothalamic-pituitary-adrenal axis.

Original language	English
Pages (from-to)	319-323
Number of pages	5
Journal	Biochemical and biophysical research communications
Volume	385
Issue number	3
DOIs	https://doi.org/10.1016/j.bbrc.2009.05.054
Publication status	Published - 2009 Jul 31
Externally published	Yes

Keywords

Activin E
Aggression
Anxiety
Transgenic mouse

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2009.05.054

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title = "Abnormalities in aggression and anxiety in transgenic mice overexpressing activin E",

abstract = "To study the function of activin E, a TGF-β superfamily member, in the regulation of affective behavior, we investigated the behavior of transgenic mice overexpressing activin E (TgActβE mice). Male TgActβE mice showed aggressive behavior in resident-intruder tests. In elevated plus-maze tests, the percentage of open arm entries was significantly increased in female TgActβE mice compared with that in wild-type mice. Furthermore, female TgActβE mice stayed in the central area for a significantly longer time than wild-type mice in open field tests. These results indicated that TgActβE mice had less anxiety-like behavior. The number of restraint-stress-evoked c-Fos-positive cells in the hypothalamic paraventricular nucleus in TgActβE mice was significantly decreased compared with that in wild-type mice. This suggests that synthesis of corticotrophin-releasing hormone induced by stress was decreased in TgActβE mice. Taking these results together, activin E may act as a regulator of the hypothalamic-pituitary-adrenal axis.",

keywords = "Activin E, Aggression, Anxiety, Transgenic mouse",

author = "Kazunari Sekiyama and Osamu Hashimoto and Yuuki Ushiro and Chika Adachi and Takefumi Kikusui and Kentaro Tanemura and Yoshihisa Hasegawa",

note = "Funding Information: We are grateful to Dr. Masayuki Funaba for helpful discussion. This work was supported by KAKENHI from the Japan Society for the Promotion of Science (to O.H.) and a Grant for Scientific Research from Kitasato University, School of Veterinary Medicine and Animal Sciences (to O.H.). Copyright: Copyright 2009 Elsevier B.V., All rights reserved.",

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doi = "10.1016/j.bbrc.2009.05.054",

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AU - Sekiyama, Kazunari

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AU - Ushiro, Yuuki

AU - Adachi, Chika

AU - Kikusui, Takefumi

AU - Tanemura, Kentaro

AU - Hasegawa, Yoshihisa

N1 - Funding Information: We are grateful to Dr. Masayuki Funaba for helpful discussion. This work was supported by KAKENHI from the Japan Society for the Promotion of Science (to O.H.) and a Grant for Scientific Research from Kitasato University, School of Veterinary Medicine and Animal Sciences (to O.H.). Copyright: Copyright 2009 Elsevier B.V., All rights reserved.

PY - 2009/7/31

Y1 - 2009/7/31

N2 - To study the function of activin E, a TGF-β superfamily member, in the regulation of affective behavior, we investigated the behavior of transgenic mice overexpressing activin E (TgActβE mice). Male TgActβE mice showed aggressive behavior in resident-intruder tests. In elevated plus-maze tests, the percentage of open arm entries was significantly increased in female TgActβE mice compared with that in wild-type mice. Furthermore, female TgActβE mice stayed in the central area for a significantly longer time than wild-type mice in open field tests. These results indicated that TgActβE mice had less anxiety-like behavior. The number of restraint-stress-evoked c-Fos-positive cells in the hypothalamic paraventricular nucleus in TgActβE mice was significantly decreased compared with that in wild-type mice. This suggests that synthesis of corticotrophin-releasing hormone induced by stress was decreased in TgActβE mice. Taking these results together, activin E may act as a regulator of the hypothalamic-pituitary-adrenal axis.

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Abnormalities in aggression and anxiety in transgenic mice overexpressing activin E

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