TY - JOUR
T1 - Abnormal white matter lesions with sensorineural hearing loss caused by congenital cytomegalovirus infection
T2 - Retrospective diagnosis by PCR using Guthrie cards
AU - Haginoya, Kazuhiro
AU - Ohura, Toshihiro
AU - Kon, Kimiya
AU - Yagi, Tsuneo
AU - Sawaishi, Yukio
AU - Ishii, Keiko Kumura
AU - Funato, Tadao
AU - Higano, Shuichi
AU - Takahashi, Shoki
AU - Iinuma, Kazuie
PY - 2002/10
Y1 - 2002/10
N2 - We report on two patients with congenital cytomegalovirus (CMV) infection asymptomatic at birth that was diagnosed retrospectively by polymerase chain reaction (PCR) of CMV DNA using blood stored on Guthrie cards. Neuroimaging studies showed abnormal myelination without any gray matter abnormalities. In the differential diagnosis of patients with abnormal white matter lesions and sensorineural hearing loss, one should consider congenital CMV infection. When investigating the etiology of patients with behavioral problems, migrational disorder, or white matter disease, PCR analysis of CMV DNA using blood stored on Guthrie cards might be helpful.
AB - We report on two patients with congenital cytomegalovirus (CMV) infection asymptomatic at birth that was diagnosed retrospectively by polymerase chain reaction (PCR) of CMV DNA using blood stored on Guthrie cards. Neuroimaging studies showed abnormal myelination without any gray matter abnormalities. In the differential diagnosis of patients with abnormal white matter lesions and sensorineural hearing loss, one should consider congenital CMV infection. When investigating the etiology of patients with behavioral problems, migrational disorder, or white matter disease, PCR analysis of CMV DNA using blood stored on Guthrie cards might be helpful.
KW - Congenital infection
KW - Cytomegalovirus
KW - Dysmyelination
KW - Newborn mass screening
KW - Polymerase chain reaction
UR - http://www.scopus.com/inward/record.url?scp=0036808364&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036808364&partnerID=8YFLogxK
U2 - 10.1016/S0387-7604(02)00088-8
DO - 10.1016/S0387-7604(02)00088-8
M3 - Article
C2 - 12427519
AN - SCOPUS:0036808364
VL - 24
SP - 710
EP - 714
JO - Brain and Development
JF - Brain and Development
SN - 0387-7604
IS - 7
ER -