Abnormal white matter lesions with sensorineural hearing loss caused by congenital cytomegalovirus infection: Retrospective diagnosis by PCR using Guthrie cards

Kazuhiro Haginoya; Toshihiro Ohura; Kimiya Kon; Tsuneo Yagi; Yukio Sawaishi; Keiko Kumura Ishii; Tadao Funato; Shuichi Higano; Syouki Takahashi; Kazuie Iinuma

doi:10.1016/S0387-7604(02)00088-8

Abnormal white matter lesions with sensorineural hearing loss caused by congenital cytomegalovirus infection: Retrospective diagnosis by PCR using Guthrie cards

Kazuhiro Haginoya, Toshihiro Ohura, Kimiya Kon, Tsuneo Yagi, Yukio Sawaishi, Keiko Kumura Ishii, Tadao Funato, Shuichi Higano, Syouki Takahashi, Kazuie Iinuma

MED - Health Sciences

Research output: Contribution to journal › Article

40 Citations (Scopus)

Abstract

We report on two patients with congenital cytomegalovirus (CMV) infection asymptomatic at birth that was diagnosed retrospectively by polymerase chain reaction (PCR) of CMV DNA using blood stored on Guthrie cards. Neuroimaging studies showed abnormal myelination without any gray matter abnormalities. In the differential diagnosis of patients with abnormal white matter lesions and sensorineural hearing loss, one should consider congenital CMV infection. When investigating the etiology of patients with behavioral problems, migrational disorder, or white matter disease, PCR analysis of CMV DNA using blood stored on Guthrie cards might be helpful.

Original language	English
Pages (from-to)	710-714
Number of pages	5
Journal	Brain and Development
Volume	24
Issue number	7
DOIs	https://doi.org/10.1016/S0387-7604(02)00088-8
Publication status	Published - 2002 Oct 1

Keywords

Congenital infection
Cytomegalovirus
Dysmyelination
Newborn mass screening
Polymerase chain reaction

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Developmental Neuroscience
Clinical Neurology

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Haginoya, K., Ohura, T., Kon, K., Yagi, T., Sawaishi, Y., Ishii, K. K., Funato, T., Higano, S., Takahashi, S., & Iinuma, K. (2002). Abnormal white matter lesions with sensorineural hearing loss caused by congenital cytomegalovirus infection: Retrospective diagnosis by PCR using Guthrie cards. Brain and Development, 24(7), 710-714. https://doi.org/10.1016/S0387-7604(02)00088-8

Abnormal white matter lesions with sensorineural hearing loss caused by congenital cytomegalovirus infection : Retrospective diagnosis by PCR using Guthrie cards. / Haginoya, Kazuhiro; Ohura, Toshihiro; Kon, Kimiya; Yagi, Tsuneo; Sawaishi, Yukio; Ishii, Keiko Kumura; Funato, Tadao; Higano, Shuichi; Takahashi, Syouki; Iinuma, Kazuie.

In: Brain and Development, Vol. 24, No. 7, 01.10.2002, p. 710-714.

Research output: Contribution to journal › Article

Haginoya, K, Ohura, T, Kon, K, Yagi, T, Sawaishi, Y, Ishii, KK, Funato, T, Higano, S, Takahashi, S & Iinuma, K 2002, 'Abnormal white matter lesions with sensorineural hearing loss caused by congenital cytomegalovirus infection: Retrospective diagnosis by PCR using Guthrie cards', Brain and Development, vol. 24, no. 7, pp. 710-714. https://doi.org/10.1016/S0387-7604(02)00088-8

Haginoya, Kazuhiro ; Ohura, Toshihiro ; Kon, Kimiya ; Yagi, Tsuneo ; Sawaishi, Yukio ; Ishii, Keiko Kumura ; Funato, Tadao ; Higano, Shuichi ; Takahashi, Syouki ; Iinuma, Kazuie. / Abnormal white matter lesions with sensorineural hearing loss caused by congenital cytomegalovirus infection : Retrospective diagnosis by PCR using Guthrie cards. In: Brain and Development. 2002 ; Vol. 24, No. 7. pp. 710-714.

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