Abnormal white matter lesions with sensorineural hearing loss caused by congenital cytomegalovirus infection: Retrospective diagnosis by PCR using Guthrie cards

Kazuhiro Haginoya, Toshihiro Ohura, Kimiya Kon, Tsuneo Yagi, Yukio Sawaishi, Keiko Kumura Ishii, Tadao Funato, Shuichi Higano, Syouki Takahashi, Kazuie Iinuma

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

We report on two patients with congenital cytomegalovirus (CMV) infection asymptomatic at birth that was diagnosed retrospectively by polymerase chain reaction (PCR) of CMV DNA using blood stored on Guthrie cards. Neuroimaging studies showed abnormal myelination without any gray matter abnormalities. In the differential diagnosis of patients with abnormal white matter lesions and sensorineural hearing loss, one should consider congenital CMV infection. When investigating the etiology of patients with behavioral problems, migrational disorder, or white matter disease, PCR analysis of CMV DNA using blood stored on Guthrie cards might be helpful.

Original languageEnglish
Pages (from-to)710-714
Number of pages5
JournalBrain and Development
Volume24
Issue number7
DOIs
Publication statusPublished - 2002 Oct 1

Keywords

  • Congenital infection
  • Cytomegalovirus
  • Dysmyelination
  • Newborn mass screening
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

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    Haginoya, K., Ohura, T., Kon, K., Yagi, T., Sawaishi, Y., Ishii, K. K., Funato, T., Higano, S., Takahashi, S., & Iinuma, K. (2002). Abnormal white matter lesions with sensorineural hearing loss caused by congenital cytomegalovirus infection: Retrospective diagnosis by PCR using Guthrie cards. Brain and Development, 24(7), 710-714. https://doi.org/10.1016/S0387-7604(02)00088-8