Abnormal white matter lesions with sensorineural hearing loss caused by congenital cytomegalovirus infection: Retrospective diagnosis by PCR using Guthrie cards

Kazuhiro Haginoya; Toshihiro Ohura; Kimiya Kon; Tsuneo Yagi; Yukio Sawaishi; Keiko Kumura Ishii; Tadao Funato; Shuichi Higano; Shoki Takahashi; Kazuie Iinuma

doi:10.1016/S0387-7604(02)00088-8

Abnormal white matter lesions with sensorineural hearing loss caused by congenital cytomegalovirus infection: Retrospective diagnosis by PCR using Guthrie cards

Kazuhiro Haginoya, Toshihiro Ohura, Kimiya Kon, Tsuneo Yagi, Yukio Sawaishi, Keiko Kumura Ishii, Tadao Funato, Shuichi Higano, Shoki Takahashi, Kazuie Iinuma

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

We report on two patients with congenital cytomegalovirus (CMV) infection asymptomatic at birth that was diagnosed retrospectively by polymerase chain reaction (PCR) of CMV DNA using blood stored on Guthrie cards. Neuroimaging studies showed abnormal myelination without any gray matter abnormalities. In the differential diagnosis of patients with abnormal white matter lesions and sensorineural hearing loss, one should consider congenital CMV infection. When investigating the etiology of patients with behavioral problems, migrational disorder, or white matter disease, PCR analysis of CMV DNA using blood stored on Guthrie cards might be helpful.

Original language	English
Pages (from-to)	710-714
Number of pages	5
Journal	Brain and Development
Volume	24
Issue number	7
DOIs	https://doi.org/10.1016/S0387-7604(02)00088-8
Publication status	Published - 2002 Oct

Keywords

Congenital infection
Cytomegalovirus
Dysmyelination
Newborn mass screening
Polymerase chain reaction

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Developmental Neuroscience
Clinical Neurology

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Haginoya, K., Ohura, T., Kon, K., Yagi, T., Sawaishi, Y., Ishii, K. K., Funato, T., Higano, S., Takahashi, S., & Iinuma, K. (2002). Abnormal white matter lesions with sensorineural hearing loss caused by congenital cytomegalovirus infection: Retrospective diagnosis by PCR using Guthrie cards. Brain and Development, 24(7), 710-714. https://doi.org/10.1016/S0387-7604(02)00088-8

Haginoya, K, Ohura, T, Kon, K, Yagi, T, Sawaishi, Y, Ishii, KK, Funato, T, Higano, S, Takahashi, S & Iinuma, K 2002, 'Abnormal white matter lesions with sensorineural hearing loss caused by congenital cytomegalovirus infection: Retrospective diagnosis by PCR using Guthrie cards', Brain and Development, vol. 24, no. 7, pp. 710-714. https://doi.org/10.1016/S0387-7604(02)00088-8

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abstract = "We report on two patients with congenital cytomegalovirus (CMV) infection asymptomatic at birth that was diagnosed retrospectively by polymerase chain reaction (PCR) of CMV DNA using blood stored on Guthrie cards. Neuroimaging studies showed abnormal myelination without any gray matter abnormalities. In the differential diagnosis of patients with abnormal white matter lesions and sensorineural hearing loss, one should consider congenital CMV infection. When investigating the etiology of patients with behavioral problems, migrational disorder, or white matter disease, PCR analysis of CMV DNA using blood stored on Guthrie cards might be helpful.",

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author = "Kazuhiro Haginoya and Toshihiro Ohura and Kimiya Kon and Tsuneo Yagi and Yukio Sawaishi and Ishii, {Keiko Kumura} and Tadao Funato and Shuichi Higano and Shoki Takahashi and Kazuie Iinuma",

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T2 - Retrospective diagnosis by PCR using Guthrie cards

AU - Haginoya, Kazuhiro

AU - Ohura, Toshihiro

AU - Kon, Kimiya

AU - Yagi, Tsuneo

AU - Sawaishi, Yukio

AU - Ishii, Keiko Kumura

AU - Funato, Tadao

AU - Higano, Shuichi

AU - Takahashi, Shoki

AU - Iinuma, Kazuie

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AB - We report on two patients with congenital cytomegalovirus (CMV) infection asymptomatic at birth that was diagnosed retrospectively by polymerase chain reaction (PCR) of CMV DNA using blood stored on Guthrie cards. Neuroimaging studies showed abnormal myelination without any gray matter abnormalities. In the differential diagnosis of patients with abnormal white matter lesions and sensorineural hearing loss, one should consider congenital CMV infection. When investigating the etiology of patients with behavioral problems, migrational disorder, or white matter disease, PCR analysis of CMV DNA using blood stored on Guthrie cards might be helpful.

KW - Congenital infection

KW - Cytomegalovirus

KW - Dysmyelination

KW - Newborn mass screening

KW - Polymerase chain reaction

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Abnormal white matter lesions with sensorineural hearing loss caused by congenital cytomegalovirus infection: Retrospective diagnosis by PCR using Guthrie cards

Abstract

Keywords

ASJC Scopus subject areas

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