Abnormal uterus with polycysts, accumulation of uterine prostaglandins, and reduced fertility in mice heterozygous for Acyl-CoA synthetase 4 deficiency

Yong Yeon Cho, Man Jong Kang, Hideyuki Sone, Takashi Suzuki, Makoto Abe, Miki Igarashi, Tomoyuki Tokunaga, Shigeki Ogawa, Yumiko A. Takei, Teruo Miyazawa, Hironobu Sasano, Takahiro Fujino, Tokuo T. Yamamoto

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

Arachidonate released by various stimuli is rapidly reesterified into membrane phospholipids initiated by acyl-CoA synthetase (ACS) and subsequent acyl-transfer reactions. ACS4 is an arachidonate-preferring enzyme abundant in steroidogenic tissues and postulated to modulate eicosanoid production. Female mice heterozygous for ACS4 deficiency become pregnant less frequently and produce small litters with extremely low transmission of the disrupted alleles. Striking morphological changes, including extremely enlarged uteri and lumina filled with numerous proliferative cysts of various sizes, were detected in ACS4+/- females. Furthermore, marked accumulation of prostaglandins was seen in the uterus of the heterozygous females. These results indicate that ACS4 modulates female fertility and uterine prostaglandin production.

Original languageEnglish
Pages (from-to)993-997
Number of pages5
JournalBiochemical and biophysical research communications
Volume284
Issue number4
DOIs
Publication statusPublished - 2001

Keywords

  • Acyl-CoA synthetase
  • Arachidonate
  • Prostaglandin
  • Reproduction

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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