TY - JOUR
T1 - Abnormal morphology of blood vessels in erythematous skin from atopic dermatitis patients
AU - Tsutsumi, Moe
AU - Fukuda, Maki
AU - Kumamoto, Junichi
AU - Goto, Makiko
AU - Denda, Sumiko
AU - Yamasaki, Kenshi
AU - Aiba, Setsuya
AU - Nagayama, Masaharu
AU - Denda, Mitsuhiro
N1 - Publisher Copyright:
© 2015 Wolters Kluwer Health, Inc.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Previous studies suggest that altered peripheral blood circulation might be associated with erythema or inflammation in atopic dermatitis (AD) patients. However, the overall structure of blood vessels and capillaries in AD skin is poorly understood because most studies have involved light-microscopic observation of thin skin sections. In the present study, we compared the 3-dimensional structures of peripheral blood vessels of healthy subjects and AD patients in detail by means of 2-photon microscopy. In skin from healthy subjects, superficial vascular plexus and capillaries originating from flexous blood vessels were observed. However, skin from AD patients contained thickened, flexuous blood vessels, which might be associated with increased blood flow, in both erythematous and nonlesional areas. However, patients with lichenification did not display these morphological changes. Bifurcation of vessels was not observed in either erythematous or lichenification lesions. These results might be helpful for developing new clinical strategies to treat erythema in AD patients.
AB - Previous studies suggest that altered peripheral blood circulation might be associated with erythema or inflammation in atopic dermatitis (AD) patients. However, the overall structure of blood vessels and capillaries in AD skin is poorly understood because most studies have involved light-microscopic observation of thin skin sections. In the present study, we compared the 3-dimensional structures of peripheral blood vessels of healthy subjects and AD patients in detail by means of 2-photon microscopy. In skin from healthy subjects, superficial vascular plexus and capillaries originating from flexous blood vessels were observed. However, skin from AD patients contained thickened, flexuous blood vessels, which might be associated with increased blood flow, in both erythematous and nonlesional areas. However, patients with lichenification did not display these morphological changes. Bifurcation of vessels was not observed in either erythematous or lichenification lesions. These results might be helpful for developing new clinical strategies to treat erythema in AD patients.
KW - peripheral blood vessel
KW - two-photon microscopy
KW - vascular plexus
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U2 - 10.1097/DAD.0000000000000373
DO - 10.1097/DAD.0000000000000373
M3 - Article
C2 - 26332534
AN - SCOPUS:84971635880
VL - 38
SP - 363
EP - 364
JO - American Journal of Dermatopathology
JF - American Journal of Dermatopathology
SN - 0193-1091
IS - 5
ER -