Aberrant progenitors common to megakaryocytic and myeloid cells in a Down's infant with transient abnormal myelopoiesis

Atsushi Sato, Masue Imaizumi, Tomoyo Noro, Ryo Ichinohasama, Toshiaki Saito, Miyako Yoshinari, Naruyoshi Suwabe, Hoshiro Suzuki, Yoshitsugu Koizumi, Yan Cui, Masayuki Yamamoto, Kazuie Iinuma

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Abstract

Phenotypic characteristics of blasts were studied in a Down's infant with transient abnormal myelopoiesis (TAM). Two major subpopulations were identified: (1) CD33+CD42b+ cells with platelet peroxidase activity, the commitment of which to megakaryocytic lineage was supported by an increased expression of GATA-1 mRNA; (2) CD33+CD34+CD7+CD4+ cells with immature ultrastructure, which could be either immature megakaryocytic or myeloid cells with aberrant differentiation. Mixed colonies containing megakaryocytes and monocyte/macrophages in the peripheral blood suggested the presence of progenitors common to these subpopulations. These results may indicate that subpopulations of blasts with phenotypic diversity could be derived from aberrant common progenitors to megakaryocytic and myeloid lineages in this patient.

Original languageEnglish
Pages (from-to)811-813,815
JournalLeukemia Research
Volume19
Issue number11
DOIs
Publication statusPublished - 1995 Nov

Keywords

  • GATA-1
  • Transient abnormal myelopoiesis
  • mixed colonies
  • multilineage phenotypes

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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    Sato, A., Imaizumi, M., Noro, T., Ichinohasama, R., Saito, T., Yoshinari, M., Suwabe, N., Suzuki, H., Koizumi, Y., Cui, Y., Yamamoto, M., & Iinuma, K. (1995). Aberrant progenitors common to megakaryocytic and myeloid cells in a Down's infant with transient abnormal myelopoiesis. Leukemia Research, 19(11), 811-813,815. https://doi.org/10.1016/0145-2126(95)00065-8