Abasic-site-containing oligodeoxynucleotides as aptamers for riboflavin

N. B. Sankaran, Seiichi Nishizawa, Takehiro Seino, Keitaro Yoshimoto, Norio Teramae

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

Finding flavins: A new class of DNA-duplex aptamers that bind to riboflavin by utilizing an abasic (AP) site has been developed (see model). An optimized duplex shows high selectivity for riboflavin over flavin mononucleotide and flavin adenine dinucleotide. Such riboflavin-duplex interactions are discussed as a basis for the further development of AP-site-based DNA aptamers. (Figure Presented).

Original languageEnglish
Pages (from-to)1563-1568
Number of pages6
JournalAngewandte Chemie - International Edition
Volume45
Issue number10
DOIs
Publication statusPublished - 2006 Feb 27

Keywords

  • Abasic sites
  • Aptamers
  • Flavins
  • Fluorescence probes
  • Nucleic acids

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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