A worldwide survey of genome sequence variation provides insight into the evolutionary history of the honeybee Apis mellifera

Andreas Wallberg, Fan Han, Gustaf Wellhagen, Bjørn Dahle, Masakado Kawata, Nizar Haddad, Zilá Luz Paulino Simões, Mike H. Allsopp, Irfan Kandemir, Pilar De La Rúa, Christian W. Pirk, Matthew T. Webster

    Research output: Contribution to journalArticle

    156 Citations (Scopus)

    Abstract

    The honeybee Apis mellifera has major ecological and economic importance. We analyze patterns of genetic variation at 8.3 million SNPs, identified by sequencing 140 honeybee genomes from a worldwide sample of 14 populations at a combined total depth of 634×. These data provide insight into the evolutionary history and genetic basis of local adaptation in this species. We find evidence that population sizes have fluctuated greatly, mirroring historical fluctuations in climate, although contemporary populations have high genetic diversity, indicating the absence of domestication bottlenecks. Levels of genetic variation are strongly shaped by natural selection and are highly correlated with patterns of gene expression and DNA methylation. We identify genomic signatures of local adaptation, which are enriched in genes expressed in workers and in immune system-and sperm motility-related genes that might underlie geographic variation in reproduction, dispersal and disease resistance. This study provides a framework for future investigations into responses to pathogens and climate change in honeybees.

    Original languageEnglish
    Pages (from-to)1081-1088
    Number of pages8
    JournalNature Genetics
    Volume46
    Issue number10
    DOIs
    Publication statusPublished - 2014 Sep 26

    ASJC Scopus subject areas

    • Genetics

    Fingerprint Dive into the research topics of 'A worldwide survey of genome sequence variation provides insight into the evolutionary history of the honeybee Apis mellifera'. Together they form a unique fingerprint.

  • Cite this

    Wallberg, A., Han, F., Wellhagen, G., Dahle, B., Kawata, M., Haddad, N., Simões, Z. L. P., Allsopp, M. H., Kandemir, I., De La Rúa, P., Pirk, C. W., & Webster, M. T. (2014). A worldwide survey of genome sequence variation provides insight into the evolutionary history of the honeybee Apis mellifera. Nature Genetics, 46(10), 1081-1088. https://doi.org/10.1038/ng.3077