A working model of CaM kinase II activity in hippocampal long-term potentiation and memory

Kohji Fukunaga; Eishichi Miyamoto

doi:10.1016/S0168-0102(00)00139-5

A working model of CaM kinase II activity in hippocampal long-term potentiation and memory

Kohji Fukunaga, Eishichi Miyamoto

Research output: Contribution to journal › Article › peer-review

103 Citations (Scopus)

Abstract

Recent advances in molecular genetics provide strong evidence for a relationship between hippocampal long-term potentiation (LTP) and hippocampus-dependent memory. The α-CaM kinase II knock-out mouse and transgenic mice expressing a mutant form of CaM kinase II clearly demonstrate that CaM kinase II plays a prominent role in hippocampal LTP and hippocampus- dependent memory. Furthermore, the observation that there is a diversity of silent as well as functional synapses has shed light on the molecular basis of learning and memory during development as well as in adult brain. Here we present a working model of CaM kinase II activity as a memory molecule in hippocampal LTP and describe molecular targets of CaM kinase II involved in the establishment of functional synapses following LTP induction. (C) 2000 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	3-17
Number of pages	15
Journal	Neuroscience Research
Volume	38
Issue number	1
DOIs	https://doi.org/10.1016/S0168-0102(00)00139-5
Publication status	Published - 2000 Sep 1
Externally published	Yes

Keywords

CaM kinase II
Hippocampus
Long-term depression
Long-term potentiation
Memory

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0168-0102(00)00139-5

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abstract = "Recent advances in molecular genetics provide strong evidence for a relationship between hippocampal long-term potentiation (LTP) and hippocampus-dependent memory. The α-CaM kinase II knock-out mouse and transgenic mice expressing a mutant form of CaM kinase II clearly demonstrate that CaM kinase II plays a prominent role in hippocampal LTP and hippocampus- dependent memory. Furthermore, the observation that there is a diversity of silent as well as functional synapses has shed light on the molecular basis of learning and memory during development as well as in adult brain. Here we present a working model of CaM kinase II activity as a memory molecule in hippocampal LTP and describe molecular targets of CaM kinase II involved in the establishment of functional synapses following LTP induction. (C) 2000 Elsevier Science Ireland Ltd.",

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AU - Fukunaga, Kohji

AU - Miyamoto, Eishichi

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N2 - Recent advances in molecular genetics provide strong evidence for a relationship between hippocampal long-term potentiation (LTP) and hippocampus-dependent memory. The α-CaM kinase II knock-out mouse and transgenic mice expressing a mutant form of CaM kinase II clearly demonstrate that CaM kinase II plays a prominent role in hippocampal LTP and hippocampus- dependent memory. Furthermore, the observation that there is a diversity of silent as well as functional synapses has shed light on the molecular basis of learning and memory during development as well as in adult brain. Here we present a working model of CaM kinase II activity as a memory molecule in hippocampal LTP and describe molecular targets of CaM kinase II involved in the establishment of functional synapses following LTP induction. (C) 2000 Elsevier Science Ireland Ltd.

AB - Recent advances in molecular genetics provide strong evidence for a relationship between hippocampal long-term potentiation (LTP) and hippocampus-dependent memory. The α-CaM kinase II knock-out mouse and transgenic mice expressing a mutant form of CaM kinase II clearly demonstrate that CaM kinase II plays a prominent role in hippocampal LTP and hippocampus- dependent memory. Furthermore, the observation that there is a diversity of silent as well as functional synapses has shed light on the molecular basis of learning and memory during development as well as in adult brain. Here we present a working model of CaM kinase II activity as a memory molecule in hippocampal LTP and describe molecular targets of CaM kinase II involved in the establishment of functional synapses following LTP induction. (C) 2000 Elsevier Science Ireland Ltd.

KW - CaM kinase II

KW - Hippocampus

KW - Long-term depression

KW - Long-term potentiation

KW - Memory

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A working model of CaM kinase II activity in hippocampal long-term potentiation and memory

Abstract

Keywords

ASJC Scopus subject areas

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