A working model of CaM kinase II activity in hippocampal long-term potentiation and memory

Kohji Fukunaga, Eishichi Miyamoto

Research output: Contribution to journalArticlepeer-review

101 Citations (Scopus)

Abstract

Recent advances in molecular genetics provide strong evidence for a relationship between hippocampal long-term potentiation (LTP) and hippocampus-dependent memory. The α-CaM kinase II knock-out mouse and transgenic mice expressing a mutant form of CaM kinase II clearly demonstrate that CaM kinase II plays a prominent role in hippocampal LTP and hippocampus- dependent memory. Furthermore, the observation that there is a diversity of silent as well as functional synapses has shed light on the molecular basis of learning and memory during development as well as in adult brain. Here we present a working model of CaM kinase II activity as a memory molecule in hippocampal LTP and describe molecular targets of CaM kinase II involved in the establishment of functional synapses following LTP induction. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)3-17
Number of pages15
JournalNeuroscience Research
Volume38
Issue number1
DOIs
Publication statusPublished - 2000 Sep 1
Externally publishedYes

Keywords

  • CaM kinase II
  • Hippocampus
  • Long-term depression
  • Long-term potentiation
  • Memory

ASJC Scopus subject areas

  • Neuroscience(all)

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