A unified total synthesis of aspergillides A and B

Haruhiko Fuwa, Hiroshi Yamaguchi, Makoto Sasaki

    Research output: Contribution to journalArticle

    67 Citations (Scopus)

    Abstract

    An enantioselective total synthesis of aspergillides A and B has been accomplished based on a unified strategy, wherein a hydroxy-directed, highly chemoselective olefin cross-metathesis and a diastereoselective intramolecular oxa-conjugate cyclization were employed to forge the 2,6-substituted tetrahydropyran substructure.

    Original languageEnglish
    Pages (from-to)1848-1851
    Number of pages4
    JournalOrganic letters
    Volume12
    Issue number8
    DOIs
    Publication statusPublished - 2010 Apr 16

    ASJC Scopus subject areas

    • Biochemistry
    • Physical and Theoretical Chemistry
    • Organic Chemistry

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