TY - JOUR
T1 - A tumefactive anti-MOG antibody associated disorder heralding central nervous system B-cell lymphoma
T2 - Case report on diagnostic challenge
AU - Uzura, Yasunori
AU - Takeuchi, Hayato
AU - Ashida, Shinji
AU - Fujii, Chihiro
AU - Shishido-Hara, Yukiko
AU - Inaba, Tohru
AU - Takai, Yoshiki
AU - Akazawa, Kentaro
AU - Mizuno, Toshiki
AU - Hashimoto, Naoya
N1 - Funding Information:
None.
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/4/15
Y1 - 2022/4/15
N2 - We present the case of a 52-year-old woman with right hemiparesis due to a mass lesion in the left parietal white matter and corpus callosum. The lesion was hyperintense on diffusion weighted image and homogenously enhanced with gadolinium on magnetic resonance imaging, and was radiologically indistinguishable with lymphoma. Following progressive aggravation of symptoms, craniotomy for biopsy of the lesion was performed, and it was revealed that the patient had anti-myelin oligodendrocyte glycoprotein-associated disease by histopathological and serological diagnosis. Initial treatment with steroid dramatically improved the symptoms, but they exacerbated again. Then, through cerebrospinal fluid examination, it was revealed that the patient had B-cell lymphoma.
AB - We present the case of a 52-year-old woman with right hemiparesis due to a mass lesion in the left parietal white matter and corpus callosum. The lesion was hyperintense on diffusion weighted image and homogenously enhanced with gadolinium on magnetic resonance imaging, and was radiologically indistinguishable with lymphoma. Following progressive aggravation of symptoms, craniotomy for biopsy of the lesion was performed, and it was revealed that the patient had anti-myelin oligodendrocyte glycoprotein-associated disease by histopathological and serological diagnosis. Initial treatment with steroid dramatically improved the symptoms, but they exacerbated again. Then, through cerebrospinal fluid examination, it was revealed that the patient had B-cell lymphoma.
KW - Anti-myelin oligodendrocyte glycoprotein antibody associated disorders
KW - Flow cytometry
KW - Primary central nervous system lymphoma
KW - Regional cerebral blood flow
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U2 - 10.1016/j.jneuroim.2022.577823
DO - 10.1016/j.jneuroim.2022.577823
M3 - Article
C2 - 35158108
AN - SCOPUS:85124382738
SN - 0165-5728
VL - 365
JO - Advances in Neuroimmunology
JF - Advances in Neuroimmunology
M1 - 577823
ER -