A total synthesis of spiruchostatin A

Takayuki Doi, Yusuke Iijima, Kazuo Shin-Ya, A. Ganesan, Takashi Takahashi

Research output: Contribution to journalArticlepeer-review

58 Citations (Scopus)

Abstract

We achieved the total synthesis of the histone deacetylase inhibitor spiruchostatin A, as the prelude to the preparation of a combinatorial library of its analogues. Two key reactions were an asymmetric acetate aldol reaction using a Zr-enolate and macrolactonization using the Shiina method.

Original languageEnglish
Pages (from-to)1177-1180
Number of pages4
JournalTetrahedron Letters
Volume47
Issue number7
DOIs
Publication statusPublished - 2006 Feb 13
Externally publishedYes

Keywords

  • Asymmetric aldol reaction
  • Cyclic depsipeptide
  • Natural product synthesis
  • Spiruchostatin

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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